Literature DB >> 823833

Effect of barbiturates on synaptic currents.

T A Torda, P W Gage.   

Abstract

Thiopentone and pentobarbitone reduce the time constant of decay of miniature end-plate currents when applied in anaesthetic concentrations to the neuromuscular junction. Such an effect at central synapses would lead to failure of synaptic transmission in the central nervous system and may reflect a common mode of action of many anaesthetic drugs.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 823833     DOI： 10.1177/0310057X7600400305

Source DB:  PubMed          Journal:  Anaesth Intensive Care        ISSN： 0310-057X            Impact factor:   1.669


  4 in total

1.  Octanol reduces end-plate channel lifetime.

Authors:  P W Gage; R N McBurney; D Van Helden
Journal:  J Physiol       Date:  1978-01       Impact factor: 5.182

2.  Postsynaptic effects of some central stimulants at the neuromuscular junction.

Authors:  P W Gage; P Sah
Journal:  Br J Pharmacol       Date:  1982-03       Impact factor: 8.739

3.  Presynaptic and postsynaptic depressant effects of phenytoin sodium at the neuromuscular junction.

Authors:  P W Gage; M Lonergan; T A Torda
Journal:  Br J Pharmacol       Date:  1980-05       Impact factor: 8.739

4.  Effects of pentobarbitone on acetylcholine-activated channels in mammalian muscle.

Authors:  P W Gage; D McKinnon
Journal:  Br J Pharmacol       Date:  1985-05       Impact factor: 8.739
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.