Literature DB >> 8237323

Transforming growth factor-beta enhances fracture healing in rabbit tibiae.

M Lind1, B Schumacker, K Søballe, J Keller, F Melsen, C Bünger.   

Abstract

The ability of exogenous Transforming Growth Factor-beta (TGF-beta) to stimulate bone formation in fracture healing was investigated. TGF-beta was continuously applied in doses of 1 and 10 micrograms/day for 6 weeks to 2 groups of adult rabbits with unilateral plated mid-tibial osteotomies. A group receiving solvent without TGF-beta served as control. Fracture healing was evaluated by mechanical tests, bone morphometry and bone densitometry. Increased maximal bending strength and callus formation were demonstrated in the groups receiving TGF-beta. TGF-beta had no effect on bending-stiffness, bone mineral content, cortical thickness or haversian canal diameter. We conclude that local application of exogenous TGF-beta may enhance fracture healing in rabbits.

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Year:  1993        PMID： 8237323     DOI： 10.3109/17453679308993691

Source DB:  PubMed          Journal:  Acta Orthop Scand        ISSN： 0001-6470


  18 in total

1.  Dose-dependent effects of combined IGF-I and TGF-beta1 application in a sheep cervical spine fusion model.

Authors:  F Kandziora; R Pflugmacher; M Scholz; J Schäfer; G Schollmeier; G Schmidmaier; G Duda; M Raschke; N P Haas
Journal:  Eur Spine J       Date:  2002-11-08       Impact factor: 3.134

Review 2.  Regulation of postnatal bone homeostasis by TGFβ.

Authors:  Simon Y Tang; Tamara Alliston
Journal:  Bonekey Rep       Date:  2013-01-09

3.  Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.

Authors:  Nagat Frara; Samir M Abdelmagid; Gregory R Sondag; Fouad M Moussa; Vanessa R Yingling; Thomas A Owen; Steven N Popoff; Mary F Barbe; Fayez F Safadi
Journal:  J Cell Physiol       Date:  2016-01       Impact factor: 6.384

4.  Evaluation of bone regeneration in implants composed of hollow HA microspheres loaded with transforming growth factor β1 in a rat calvarial defect model.

Authors:  Hailuo Fu; Mohamed N Rahaman; Roger F Brown; Delbert E Day
Journal:  Acta Biomater       Date:  2012-11-17       Impact factor: 8.947

5.  Loss of scleraxis in mice leads to geometric and structural changes in cortical bone, as well as asymmetry in fracture healing.

Authors:  Jennifer A McKenzie; Evan Buettmann; Adam C Abraham; Michael J Gardner; Matthew J Silva; Megan L Killian
Journal:  FASEB J       Date:  2016-11-18       Impact factor: 5.191

6.  Alcohol inhibits osteopontin-dependent transforming growth factor-β1 expression in human mesenchymal stem cells.

Authors:  Joseph Driver; Cynthia E Weber; John J Callaci; Anai N Kothari; Matthew A Zapf; Philip M Roper; Dariusz Borys; Carrie A Franzen; Gopal N Gupta; Philip Y Wai; Jiwang Zhang; Mitchell F Denning; Paul C Kuo; Zhiyong Mi
Journal:  J Biol Chem       Date:  2015-02-24       Impact factor: 5.157

7.  Anterior lumbar interbody fusion with carbon fiber cage loaded with bioceramics and platelet-rich plasma. An experimental study on pigs.

Authors:  Haisheng Li; Xuenong Zou; Qingyun Xue; Niels Egund; Martin Lind; Cody Bünger
Journal:  Eur Spine J       Date:  2004-01-17       Impact factor: 3.134

8.  [Influence of local application of basic fibroblast growth factor on resistance to local infection after standardized closed soft tissue trauma. An experimental study in rats].

Authors:  T Kälicke; O Sprutacz; U Schlegel; F Kutscha-Lissberg; M Köller; G Printzen; G Muhr; S Arens
Journal:  Unfallchirurg       Date:  2004-03       Impact factor: 1.000

9.  Elevated transforming growth factor-beta 1 (TGF-β1) levels in human fracture healing.

Authors:  Kambiz Sarahrudi; Anita Thomas; Mehdi Mousavi; Georg Kaiser; Julia Köttstorfer; Mathias Kecht; S Hajdu; S Aharinejad
Journal:  Injury       Date:  2011-05-06       Impact factor: 2.586

10.  Effects of TGF-β1 and VEGF-A transgenes on the osteogenic potential of bone marrow stromal cells in vitro and in vivo.

Authors:  Shinji Kuroda; Dale R Sumner; Amarjit S Virdi
Journal:  J Tissue Eng       Date:  2012-09-04       Impact factor: 7.813
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