| Literature DB >> 8236361 |
A M Gardier1, D Mathé, X Guédeney, J Barré, C Benvenutti, N Navarro, L Vernillet, D Loisance, J P Cachera, B Jacotot.
Abstract
The present study attempted to characterize the distribution of cyclosporin A (CsA) among the lipoprotein fractions, very-low-, intermediate-, low-, and high-density (VLDL, IDL, LDL, and HDL, respectively) in the plasma of patients awaiting heart transplantation and the influence of plasma lipid constituents on the pharmacokinetics of CsA. Major fractions of a therapeutic concentration of CsA were found in HDL and in LDL. In addition, plasma lipid concentrations (total cholesterol, triglycerides, phospholipids, VLDL-cholesterol--TC, TG, PL, VLDLc, respectively) are positively correlated with the CsA distribution within the LDL fraction, and negatively correlated with the CsA distribution within the HDL fraction. Thus, the percentage of CsA in each type of lipoproteins was shown to vary with the lipid levels among individuals. A significant negative correlation was found between apparent distribution volume at steady state (Vss) in plasma and TC, PL, and LDLc and between the area under the curve measured in blood (AUCB) for whole blood and PL.Entities:
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Year: 1993 PMID： 8236361 DOI： 10.1097/00007691-199308000-00003
Source DB: PubMed Journal: Ther Drug Monit ISSN： 0163-4356 Impact factor: 3.681