Literature DB >> 823564

Effects of amitriptyline and isocarboxazid on 5-hydroxytryptophan induced head twitches in mice.

M Nakamura, H Fukushima, S Kitagawa.   

Abstract

Effects of amitriptyline and isocarboxazid on brain 5-HT and 5-HIAA were examined in relation to their action on 5-HTP induced head twitches. Amitriptyline reduced 5-HTP induced head twitches but isocarboxazid increased them. Both amitriptyline and isocarboxazid caused a significant increase of brain 5-HT concentration in 5-HTP treated mice. Amitriptyline also caused a significant increase of 5-HIAA concentration, while isocarboxazid reduced 5-HIAA concentration in the brains of 5-HTP treated mice. Probenecid, which significantly increased 5-HIAA concentration without affecting brain 5-HT concentration in 5-HTP treated mice, reduced 5-HTP induced heat twitches. These results suggest that 5-HTP induced head twitches might be induced by an increase of 5-HT concentration, and reduced by an increase of 5-HIAA or a decrease of 5-HT concentration in the brains of mice.

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Year:  1976        PMID： 823564     DOI： 10.1007/BF00423314

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  15 in total

1.  INFLUENCE OF IMIPRAMINE AND RELATED PSYCHOACTIVE AGENTS ON THE EFFECT OF 5-HYDROXYTRYPTAMINE AND CATECHOLAMINES ON THE CAT NICTITATING MEMBRANE.

Authors:  E B SIGG; L SOFFER; L GYERMEK
Journal:  J Pharmacol Exp Ther       Date:  1963-10       Impact factor: 4.030

2.  Assay of serotonin and related metabolites, enzymes, and drugs.

Authors:  S UDENFRIEND; H WEISSBACH; B B BRODIE
Journal:  Methods Biochem Anal       Date:  1958

3.  Possible involvement of 5-hydroxytryptamine in the antidepressant activity of narcotic analgesics.

Authors:  N S Doggett; H Reno; S J Spencer
Journal:  Neuropharmacology       Date:  1975-02       Impact factor: 5.250

4.  Proceedings: Cyclic nucleotides and ethanol withdrawal head-twitches in mice.

Authors:  M D Hammond; C Schneider
Journal:  Br J Pharmacol       Date:  1974-09       Impact factor: 8.739

5.  Effects of reserpine and desipramine on the uptake and subcellular distribution of 5-hydroxytryptamine in rabbit brain stem after intravenous administration of 5-hydroxytryptophan.

Authors:  T Segawa
Journal:  Jpn J Pharmacol       Date:  1970-03

6.  Replenishment by 5-hydroxytryptophan of the amine stores in the central 5-hydroxytryptamine neurons after depletion induced by reserpine or by an inhibitor of monoamine synthesis.

Authors:  H Corrodi; K Fuxe; T Hökfelt
Journal:  J Pharm Pharmacol       Date:  1967-07       Impact factor: 3.765

7.  Demonstration of extraneuronal 5-hydroxytryptamine accumulation in brain following membrane-pump blockade by chlorimipramine.

Authors:  A Carlsson; J Jonason; M Lindqvist; K Fuxe
Journal:  Brain Res       Date:  1969-02       Impact factor: 3.252

8.  Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-alpha-ethyl-meta-tyramine.

Authors:  A Carlsson; H Corrodi; K Fuxe; T Hökfelt
Journal:  Eur J Pharmacol       Date:  1969-03       Impact factor: 4.432

9.  Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,alpha-dimethyl-meta-tyramine.

Authors:  A Carlsson; H Corrodi; K Fuxe; T Hökfelt
Journal:  Eur J Pharmacol       Date:  1969-03       Impact factor: 4.432

10.  A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine.

Authors:  S J CORNE; R W PICKERING; B T WARNER
Journal:  Br J Pharmacol Chemother       Date:  1963-02
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  7 in total

1.  Neurochemical and behavioural effects of hypidone hydrochloride (YL-0919): a novel combined selective 5-HT reuptake inhibitor and partial 5-HT1A agonist.

Authors:  Li-Ming Zhang; Xiao-Yun Wang; Nan Zhao; Yu-Lu Wang; Xiao-Xu Hu; Yu-Hua Ran; Yan-Qin Liu; You-Zhi Zhang; Ri-Fang Yang; Yun-Feng Li
Journal:  Br J Pharmacol       Date:  2017-03-21       Impact factor: 8.739

2.  Head twitches induced by benzodiazepines and the role of biogenic amines.

Authors:  M Nakamura; H Fukushima
Journal:  Psychopharmacology (Berl)       Date:  1976-09-29       Impact factor: 4.530

3.  Serotonergic function in mouse head twitches induced by lithium and reserpine.

Authors:  K Yamada; T Furukawa
Journal:  Psychopharmacology (Berl)       Date:  1979-03-28       Impact factor: 4.530

4.  The involvement of serotonergic neurons in the central nervous system as the possible mechanism for slow head-shaking behavior induced by methamphetamine in rats.

Authors:  T Honma; H Fukushima
Journal:  Psychopharmacology (Berl)       Date:  1979-10       Impact factor: 4.530

5.  Effect of benzodiazepines on central serotonergic neuron systems.

Authors:  M Nakamura; H Fukushima
Journal:  Psychopharmacology (Berl)       Date:  1977-07-18       Impact factor: 4.530

6.  Circadian variation in the head twitch response produced by 5-methoxy-N1,N1-dimethyltryptamine and p-chloroamphetamine in the mouse.

Authors:  C Singleton; C A Marsden
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

7.  Head-twitch response induced by tyramine.

Authors:  S Orikasa; S Sakurada; K Kisara
Journal:  Psychopharmacology (Berl)       Date:  1980-01       Impact factor: 4.530
  7 in total

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