| Literature DB >> 8235208 |
P Pollak1, A L Benabid, C Gross, D M Gao, A Laurent, A Benazzouz, D Hoffmann, M Gentil, J Perret.
Abstract
In Parkinson's disease, experimental studies favour a neuronal hyperactivity of the subthalamic nucleus. We carried out a subthalamic nucleus electrical stimulation in a patient aged 51, suffering for 8 years from a severe akineto-rigid form of Parkinson's disease, complicated with an on-off effect. Stereotaxic surgery was done under local anaesthesia on one side. Within the theoretical target, a 130 Hz stimulation induced akinesia alleviation mainly on the contralateral limbs. No abnormal movement was noticed. Then a long-term quadripolar DBS Medtronic electrode was inserted in that area. The study of the effects of chronic stimulation is in progress to determine the best temporal and electrical stimulation variables.Entities:
Mesh:
Year: 1993 PMID: 8235208
Source DB: PubMed Journal: Rev Neurol (Paris) ISSN: 0035-3787 Impact factor: 2.607