Literature DB >> 8233040

Complement gene expression in neuroblastoma and astrocytoma cell lines of human origin.

D G Walker1, P L McGeer.   

Abstract

Activation of the complement system is believed to be involved in degenerative processes of certain neurological diseases, including Alzheimer disease. Recent data have shown that the mRNAs for these proteins can be detected in brain-derived mRNA. In this study, C4 mRNA was detected by polymerase chain reaction (PCR) amplification of mRNA from the human neuroblastoma cell lines IMR32, SK-SH and SK-MC, and the human astrocytoma cell line U373MG, while C3 expression was detected in SK-MC, SK-SH and U373MG cells. The SK-MC and U373MG cells expressed mRNA for C9. The mRNA for C1qB could not be detected in any of these cell lines.

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Year:  1993        PMID： 8233040     DOI： 10.1016/0304-3940(93)90652-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

Review 1.  Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities.

Authors:  Philippe Gasque; Jim W Neal; Sim K Singhrao; Eamon P McGreal; Yann D Dean; Beek Johan Van; B Paul Morgan
Journal:  Mol Neurobiol       Date:  2002-02       Impact factor: 5.590

2.  Up-regulated production and activation of the complement system in Alzheimer's disease brain.

Authors:  K Yasojima; C Schwab; E G McGeer; P L McGeer
Journal:  Am J Pathol       Date:  1999-03       Impact factor: 4.307

3.  The role of the complement system and the activation fragment C5a in the central nervous system.

Authors:  Trent M Woodruff; Rahasson R Ager; Andrea J Tenner; Peter G Noakes; Stephen M Taylor
Journal:  Neuromolecular Med       Date:  2009-09-11       Impact factor: 3.843

4.  Complement activation in amyloid plaques in Alzheimer's disease brains does not proceed further than C3.

Authors:  R Veerhuis; P van der Valk; I Janssen; S S Zhan; W E Van Nostrand; P Eikelenboom
Journal:  Virchows Arch       Date:  1995       Impact factor: 4.064

5.  Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients.

Authors:  M Huell; S Strauss; B Volk; M Berger; J Bauer
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

Review 6.  Innate immunity and neuroinflammation.

Authors:  Abhishek Shastri; Domenico Marco Bonifati; Uday Kishore
Journal:  Mediators Inflamm       Date:  2013-06-15       Impact factor: 4.711

Review 7.  Emerging Roles of Complement in Psychiatric Disorders.

Authors:  Mélanie Druart; Corentin Le Magueresse
Journal:  Front Psychiatry       Date:  2019-08-21       Impact factor: 4.157
  7 in total

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