Literature DB >> 8232825

Contribution of calcium ions to the generation of epileptic activity and antiepileptic calcium antagonism.

E J Speckmann1, H Straub, R Köhling.   

Abstract

With epileptic activity, neurons show paroxysmal depolarization shifts (PDSs) corresponding to epileptic field potentials (EFPs) generated by the neuronal population. Experimental results indicate that calcium and calcium-dependent currents participate in the generation of these events. Consequently neuronal PDS/EFP were depressed by organic calcium channel blockers. This justifies the hope that calcium channel blockers might be useful in the treatment of human epilepsies.

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Year:  1993        PMID： 8232825     DOI： 10.1159/000118966

Source DB:  PubMed          Journal:  Neuropsychobiology        ISSN： 0302-282X            Impact factor:   2.328


  5 in total

1.  Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain.

Authors:  Evan C Rosenberg; Jocelyn J Lippman-Bell; Marcus Handy; Samantha S Soldan; Sanjay Rakhade; Cristina Hilario-Gomez; Kaitlyn Folweiler; Leah Jacobs; Frances E Jensen
Journal:  Neurobiol Dis       Date:  2018-05-05       Impact factor: 5.996

2.  Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice.

Authors:  M Gasior; R Kamiński; T Brudniak; Z Kleinrok; S J Czuczwar
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

3.  Single dose varenicline may trigger epileptic activity.

Authors:  Haydar Ali Erken; Gülten Erken; Hasan Simşek; Oğuzhan Korkut; Emine Rabia Koç; Ozlem Yavuz; Osman Genç
Journal:  Neurol Sci       Date:  2014-06-07       Impact factor: 3.307

4.  Parental and comorbid epilepsy in persons with bipolar disorder.

Authors:  Dan Sucksdorff; Alan S Brown; Roshan Chudal; Elina Jokiranta-Olkoniemi; Susanna Leivonen; Auli Suominen; Markus Heinimaa; Andre Sourander
Journal:  J Affect Disord       Date:  2015-09-02       Impact factor: 4.839

5.  Review: Cav2.3 R-type Voltage-Gated Ca2+ Channels - Functional Implications in Convulsive and Non-convulsive Seizure Activity.

Authors:  Carola Wormuth; Andreas Lundt; Christina Henseler; Ralf Müller; Karl Broich; Anna Papazoglou; Marco Weiergräber
Journal:  Open Neurol J       Date:  2016-09-30
  5 in total

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