Literature DB >> 8232552

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.

M Müller1, J Briscoe, C Laxton, D Guschin, A Ziemiecki, O Silvennoinen, A G Harpur, G Barbieri, B A Witthuhn, C Schindler.   

Abstract

We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes.

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Year:  1993        PMID： 8232552     DOI： 10.1038/366129a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  201 in total

1.  Regulation of the Jak2 tyrosine kinase by its pseudokinase domain.

Authors:  P Saharinen; K Takaluoma; O Silvennoinen
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

2.  IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages.

Authors:  C Contursi; I M Wang; L Gabriele; M Gadina; J O'Shea; H C Morse; K Ozato
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

3.  The intracellular domain of interferon-alpha receptor 2c (IFN-alphaR2c) chain is responsible for Stat activation.

Authors:  S V Kotenko; L S Izotova; O V Mirochnitchenko; C Lee; S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

4.  Distinct mechanisms of activation of Stat1 and Stat3 by platelet-derived growth factor receptor in a cell-free system.

Authors:  M L Vignais; M Gilman
Journal:  Mol Cell Biol       Date:  1999-05       Impact factor: 4.272

5.  Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.

Authors:  A Deb; M Zamanian-Daryoush; Z Xu; S Kadereit; B R Williams
Journal:  EMBO J       Date:  2001-05-15       Impact factor: 11.598

6.  STAT1 from the cell membrane to the DNA.

Authors:  B F Lillemeier; M Köster; I M Kerr
Journal:  EMBO J       Date:  2001-05-15       Impact factor: 11.598

7.  Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.

Authors:  Y E Chin; M Kitagawa; K Kuida; R A Flavell; X Y Fu
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

Review 8.  Biology and significance of the JAK/STAT signalling pathways.

Authors:  Hiu Kiu; Sandra E Nicholson
Journal:  Growth Factors       Date:  2012-02-20       Impact factor: 2.511

9.  Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.

Authors:  B W Winston; C A Lange-Carter; A M Gardner; G L Johnson; D W Riches
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

10.  Expression and signaling specificity of the IFNAR chain of the type I interferon receptor complex.

Authors:  S N Constantinescu; E Croze; A Murti; C Wang; L Basu; D Hollander; D Russell-Harde; M Betts; V Garcia-Martinez; J E Mullersman; L M Pfeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205
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