Literature DB >> 8232351

The subthalamic nucleus: a possible target for stereotaxic surgery in Parkinson's disease.

J Guridi1, M R Luquin, M T Herrero, J A Obeso.   

Abstract

Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.

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Year:  1993        PMID： 8232351     DOI： 10.1002/mds.870080402

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  5 in total

1.  Surgery for Parkinson's disease.

Authors:  J A Obeso; J Guridi; J A Obeso; M DeLong
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-01       Impact factor: 10.154

2.  A neural model of basal ganglia-thalamocortical relations in normal and parkinsonian movement.

Authors:  J L Contreras-Vidal; G E Stelmach
Journal:  Biol Cybern       Date:  1995-10       Impact factor: 2.086

3.  Hemiballism in Parkinson's disease.

Authors:  J A Obeso; J Guridi; G Linazasoro; E Ramos
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-05       Impact factor: 10.154

4.  Deep brain stimulation for the treatment of Parkinson's disease: subthalamic nucleus versus globus pallidus internus.

Authors:  M Krause; W Fogel; A Heck; W Hacke; M Bonsanto; C Trenkwalder; V Tronnier
Journal:  J Neurol Neurosurg Psychiatry       Date:  2001-04       Impact factor: 10.154

5.  Enhancement of sensorimotor behavioral recovery in hemiparkinsonian rats with intrastriatal, intranigral, and intrasubthalamic nucleus dopaminergic transplants.

Authors:  K Mukhida; K A Baker; D Sadi; I Mendez
Journal:  J Neurosci       Date:  2001-05-15       Impact factor: 6.167
  5 in total

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