Literature DB >> 8232282

Inhibition of monoamine oxidase-A of rat brain by pyrethroids--an in vitro kinetic study.

G V Rao1, K S Rao.   

Abstract

An in vitro kinetic study on inhibition of the monoamine oxidase-A (MAO-A) of the rat brain by two pyrethroids, namely permethrin (PM) and cypermethrin (CPM), has shown that PM and CPM competitively inhibit MAO-A by altering both the Michaelis-Menten constant (Km) and the maximum velocity (Vmax). Inhibitor constant values (Ki) indicated that CPM was a more effective inhibitor of MAO-A than PM. Both PM and CPM caused maximum inhibition of MAO-A at neutral pH. CPM significantly elevated the activation energy values of MAO-A as compared to those of PM.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8232282     DOI： 10.1007/bf00929202

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  12 in total

Review 1.  Multiple forms of monoamine oxidase: fact and artefact.

Authors:  M D Houslay; K F Tipton
Journal:  Life Sci       Date:  1976-08-15       Impact factor: 5.037

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Some observations upon a new inhibitor of monoamine oxidase in brain tissue.

Authors:  J P Johnston
Journal:  Biochem Pharmacol       Date:  1968-07       Impact factor: 5.858

4.  Inhibition of rat brain monoamine oxidase by insecticides, acaricides and related compounds.

Authors:  H A Kadir; C O Knowles
Journal:  Gen Pharmacol       Date:  1981

5.  A rapid microfluorimetric determination of monoamine oxidase.

Authors:  M Krajl
Journal:  Biochem Pharmacol       Date:  1965-11       Impact factor: 5.858

6.  Inhibition of monoamine oxidase by 7-chloro-4-nitrobenzofurazan.

Authors:  R C Fu; X F Liu; S U Chen
Journal:  J Neurochem       Date:  1990-09       Impact factor: 5.372

7.  Inhibition of monoamine oxidase by the fungicide metalaxyl.

Authors:  K A Naidu
Journal:  J Toxicol Environ Health       Date:  1989

8.  The regional distribution of monoamine oxidase activities towards different substrates: effects in rat brain of chronic administration of manganese chloride and of ageing.

Authors:  T K Leung; J C Lai; L Lim
Journal:  J Neurochem       Date:  1981-06       Impact factor: 5.372

Review 9.  Neurotoxicological effects and the mode of action of pyrethroid insecticides.

Authors:  H P Vijverberg; J van den Bercken
Journal:  Crit Rev Toxicol       Date:  1990       Impact factor: 5.635

10.  Electrophysiological comparison of insecticide and alkaloid agonists of Na channels.

Authors:  M D Leibowitz; J R Schwarz; G Holan; B Hille
Journal:  J Gen Physiol       Date:  1987-07       Impact factor: 4.086
View more
  2 in total

1.  In vitro efficacy of amitraz, coumaphos, deltamethrin and lindane against engorged female Rhipicephalus (Boophilus) annulatus and Haemaphysalis bispinosa ticks.

Authors:  Reghu Ravindran; Gopi Jyothimol; Krishnan Kavillimakkil Amithamol; Athalathil Ramankutty Sunil; Leena Chandrasekhar; Dibya Ranjan Lenka; Achuthkumar Amritha; Kanapadinchareveetil Sreelekha; Nanjundappa Sathish; Darsana Udayan; Thumadath Palayullaparambil Adarsh Krishna; Thirumangalath Meethal Divya; Sanis Juliet; Karapparambu Gopalan Ajith Kumar; Suresh Narayanan Nair; Srikanta Ghosh
Journal:  Exp Appl Acarol       Date:  2018-05-08       Impact factor: 2.132

2.  MAOA, DBH, and SLC6A4 variants in CHARGE: a case-control study of autism spectrum disorders.

Authors:  Flora Tassone; Lihong Qi; Wenting Zhang; Robin L Hansen; Isaac N Pessah; Irva Hertz-Picciotto
Journal:  Autism Res       Date:  2011-04-29       Impact factor: 5.216
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.