Literature DB >> 8232257

Solution structure of bovine heart fatty acid-binding protein (H-FABPc).

D Lassen1, C Lücke, A Kromminga, A Lezius, F Spener, H Rüterjans.   

Abstract

Fatty acid-binding protein (FABP) from bovine heart, a 15 kDa cytoplasmic protein has been investigated by multi-dimensional homonuclear and heteronuclear NMR-spectroscopy. Perdeuterated palmitic acid has been used as fatty acid ligand. The tertiary structure has been determined from distance geometry calculations with the variable target functions algorithm (DIANA) utilizing 1027 interproton distance constraints, which were obtained from 1H-homonuclear NOESY spectra. Overlapping NOE crosspeaks were assigned by heteronuclear multidimensional NMR-experiments with a 15N-labelled sample. The tertiary structure resembles a beta-barrel (beta-clam) consisting of ten anti-parallel beta-strands and a short helix-turn-helix motif. The beta-strands are arranged in two nearly orthogonal beta-sheets composed of 5 strands each. The solution structure is compared with the x-ray crystal structure of bovine heart and rat intestinal FABPs.

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Year:  1993        PMID： 8232257     DOI： 10.1007/bf01076470

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  16 in total

Review 1.  Crystal structure of chicken liver basic fatty acid-binding protein at 2.7 A resolution.

Authors:  G Scapin; P Spadon; M Mammi; G Zanotti; H L Monaco
Journal:  Mol Cell Biochem       Date:  1990 Oct 15-Nov 8       Impact factor: 3.396

2.  Improved efficiency of protein structure calculations from NMR data using the program DIANA with redundant dihedral angle constraints.

Authors:  P Güntert; K Wüthrich
Journal:  J Biomol NMR       Date:  1991-11       Impact factor: 2.835

3.  Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA.

Authors:  P Güntert; W Braun; K Wüthrich
Journal:  J Mol Biol       Date:  1991-02-05       Impact factor: 5.469

Review 4.  Structural and functional features of different types of cytoplasmic fatty acid-binding proteins.

Authors:  J H Veerkamp; R A Peeters; R G Maatman
Journal:  Biochim Biophys Acta       Date:  1991-01-04

Review 5.  The cellular fatty acid binding proteins: aspects of structure, regulation, and function.

Authors:  N M Bass
Journal:  Int Rev Cytol       Date:  1988

6.  Interactions of fatty acids with neutral fatty-acid-binding protein from bovine liver.

Authors:  H Schulenberg-Schell; P Schäfer; H J Keuper; B Stanislawski; E Hoffmann; H Rüterjans; F Spener
Journal:  Eur J Biochem       Date:  1988-01-04

7.  Cardiac fatty acid-binding proteins. Isolation and characterization of the mitochondrial fatty acid-binding protein and its structural relationship with the cytosolic isoforms.

Authors:  C Unterberg; T Börchers; P Højrup; P Roepstorff; J Knudsen; F Spener
Journal:  J Biol Chem       Date:  1990-09-25       Impact factor: 5.157

8.  Isolation and characterization of the fatty acid binding protein from human heart.

Authors:  C Unterberg; G Heidl; D B von Bassewitz; F Spener
Journal:  J Lipid Res       Date:  1986-12       Impact factor: 5.922

9.  Cloning of a full-length complementary DNA for fatty-acid-binding protein from bovine heart.

Authors:  S Billich; T Wissel; H Kratzin; U Hahn; B Hagenhoff; A G Lezius; F Spener
Journal:  Eur J Biochem       Date:  1988-08-15

10.  Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate.

Authors:  J C Sacchettini; J I Gordon; L J Banaszak
Journal:  J Mol Biol       Date:  1989-07-20       Impact factor: 5.469
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  3 in total

1.  Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit.

Authors:  F Zhang; C Lücke; L J Baier; J C Sacchettini; J A Hamilton
Journal:  J Biomol NMR       Date:  1997-04       Impact factor: 2.835

2.  1H and 15N resonance assignments and secondary structure of cellular retinoic acid-binding protein with and without bound ligand.

Authors:  J Rizo; Z P Liu; L M Gierasch
Journal:  J Biomol NMR       Date:  1994-11       Impact factor: 2.835

Review 3.  Sterol carrier protein-2: new roles in regulating lipid rafts and signaling.

Authors:  Friedhelm Schroeder; Barbara P Atshaves; Avery L McIntosh; Adalberto M Gallegos; Stephen M Storey; Rebecca D Parr; John R Jefferson; Judith M Ball; Ann B Kier
Journal:  Biochim Biophys Acta       Date:  2007-04-12
  3 in total

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