Literature DB >> 8230487

Identification and characterization of an extended Tax protein in human T-cell lymphotropic virus type II subtype b isolates.

D Pardi1, J E Kaplan, J E Coligan, T M Folks, R B Lal.   

Abstract

The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-IIG12) was found to encode an extended Tax protein when compared with that of HTLV-IIMoT. In vitro transcription-translation of the HTLV-IIG12 tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.

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Year:  1993        PMID： 8230487      PMCID： PMC238237     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

1.  Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene.

Authors:  K Shimotohno; Y Takahashi; N Shimizu; T Gojobori; D W Golde; I S Chen; M Miwa; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Relative prevalence and risk factors of HTLV-I and HTLV-II infection in US blood donors.

Authors:  H H Lee; P Swanson; J D Rosenblatt; I S Chen; W C Sherwood; D E Smith; G E Tegtmeier; L P Fernando; C T Fang; M Osame
Journal:  Lancet       Date:  1991-06-15       Impact factor: 79.321

4.  Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides.

Authors:  P Horal; W W Hall; B Svennerholm; J Lycke; S Jeansson; L Rymo; M H Kaplan; A Vahlne
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

5.  Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis.

Authors:  A Gessain; F Barin; J C Vernant; O Gout; L Maurs; A Calender; G de Thé
Journal:  Lancet       Date:  1985-08-24       Impact factor: 79.321

6.  Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

Authors:  M Yoshida; M Seiki; K Yamaguchi; K Takatsuki
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

7.  A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia.

Authors:  V S Kalyanaraman; M G Sarngadharan; M Robert-Guroff; I Miyoshi; D Golde; R C Gallo
Journal:  Science       Date:  1982-11-05       Impact factor: 47.728

8.  Human T lymphotropic virus type II (HTLV-II) infection in a cohort of New York intravenous drug users: an old infection?

Authors:  R F Khabbaz; D Hartel; M Lairmore; C R Horsburgh; E E Schoenbaum; B Roberts; T M Hartley; G Friedland
Journal:  J Infect Dis       Date:  1991-02       Impact factor: 5.226

9.  Serologic discrimination of human T cell lymphotropic virus infection by using a synthetic peptide-based enzyme immunoassay.

Authors:  R B Lal; D L Rudolph; M D Lairmore; R F Khabbaz; M Garfield; J E Coligan; T M Folks
Journal:  J Infect Dis       Date:  1991-01       Impact factor: 5.226

10.  Incidence of hairy cell leukemia, mycosis fungoides, and chronic lymphocytic leukemia in first known HTLV-II-endemic population.

Authors:  B Hjelle; R Mills; S Swenson; G Mertz; C Key; S Allen
Journal:  J Infect Dis       Date:  1991-03       Impact factor: 5.226
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  5 in total

1.  Differences in the ability of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 tax to inhibit p53 function.

Authors:  R Mahieux; C A Pise-Masison; P F Lambert; C Nicot; L De Marchis; A Gessain; P Green; W Hall; J N Brady
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

2.  Identification and characterization of a new and distinct molecular subtype of human T-cell lymphotropic virus type 2.

Authors:  N Eiraku; P Novoa; M da Costa Ferreira; C Monken; R Ishak; O da Costa Ferreira; S W Zhu; R Lorenco; M Ishak; V Azvedo; J Guerreiro; M P de Oliveira; P Loureiro; N Hammerschlak; S Ijichi; W M Hall
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

3.  Molecular analysis of human T-cell lymphotropic virus type II from Wayuu Indians of Colombia demonstrates two subtypes of HTLV-IIb.

Authors:  W M Switzer; S M Owen; D A Pieniazek; V R Nerurkar; E Duenas-Barajas; W Heneine; R B Lal
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332

4.  Genotypic characteristics of HTLV-II isolates from Amerindian and non-Indian populations.

Authors:  D Pardi; B Hjelle; T M Folks; R B Lal
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332

Review 5.  Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences.

Authors:  Umberto Bertazzoni; Marco Turci; Francesca Avesani; Gianfranco Di Gennaro; Carlo Bidoia; Maria Grazia Romanelli
Journal:  Viruses       Date:  2011-05-09       Impact factor: 5.818
  5 in total

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