PURPOSE: A phase I study was undertaken to determine the toxicity and maximum-tolerated dose (MTD) of recombinant human tumor necrosis factor (rTNF) in children. PATIENTS AND METHODS: Twenty-seven patients with recurrent or refractory solid tumors were enrolled on the study. rTNF was administered daily for 5 days by 30-minute intravenous (IV) infusion, and doses were escalated in cohorts of three to six patients. Courses were repeated after a 9-day rest period, if toxicity was tolerable. Daily doses ranged from 100 to 350 micrograms/m2. RESULTS: Most courses were associated with grade I/II fever, rigors, nausea, or vomiting. Three patients experienced moderate dyspnea that responded to supplemental oxygen. All abnormalities resolved on discontinuation of the infusion. One patient had a cardiac arrest 90 minutes after receiving the first dose of rTNF and died 10 days later of related complications. In two other patients, rTNF was discontinued due to persistent grade IV hypotension. Toxicities were not consistently related to dose and no cumulative effects were noted. The dose-limiting toxicity was transient hepatic dysfunction, which occurred in three of six patients receiving 350 micrograms/m2; this toxicity was rapidly reversed on discontinuation of the rTNF. One patient, whose non-Hodgkin's lymphoma had recurred after bone marrow transplantation, had a partial response. Disease was stabilized in two patients. CONCLUSION: We recommend that phase II testing proceed at a dose of 300 micrograms/m2/d on the schedule described.
PURPOSE: A phase I study was undertaken to determine the toxicity and maximum-tolerated dose (MTD) of recombinant humantumor necrosis factor (rTNF) in children. PATIENTS AND METHODS: Twenty-seven patients with recurrent or refractory solid tumors were enrolled on the study. rTNF was administered daily for 5 days by 30-minute intravenous (IV) infusion, and doses were escalated in cohorts of three to six patients. Courses were repeated after a 9-day rest period, if toxicity was tolerable. Daily doses ranged from 100 to 350 micrograms/m2. RESULTS: Most courses were associated with grade I/II fever, rigors, nausea, or vomiting. Three patients experienced moderate dyspnea that responded to supplemental oxygen. All abnormalities resolved on discontinuation of the infusion. One patient had a cardiac arrest 90 minutes after receiving the first dose of rTNF and died 10 days later of related complications. In two other patients, rTNF was discontinued due to persistent grade IV hypotension. Toxicities were not consistently related to dose and no cumulative effects were noted. The dose-limiting toxicity was transient hepatic dysfunction, which occurred in three of six patients receiving 350 micrograms/m2; this toxicity was rapidly reversed on discontinuation of the rTNF. One patient, whose non-Hodgkin's lymphoma had recurred after bone marrow transplantation, had a partial response. Disease was stabilized in two patients. CONCLUSION: We recommend that phase II testing proceed at a dose of 300 micrograms/m2/d on the schedule described.
Authors: M Grimm; M Lazariotou; S Kircher; A Höfelmayr; C T Germer; B H A von Rahden; A M Waaga-Gasser; M Gasser Journal: Cell Oncol (Dordr) Date: 2011-08 Impact factor: 6.730
Authors: Nathan A Koonce; Charles M Quick; Matthew E Hardee; Azemat Jamshidi-Parsian; Judith A Dent; Giulio F Paciotti; Dmitry Nedosekin; Ruud P M Dings; Robert J Griffin Journal: Int J Radiat Oncol Biol Phys Date: 2015-07-26 Impact factor: 7.038
Authors: L Duan; M Aoyagi; M Tamaki; K Nakagawa; G Nagashima; Y Nagasaka; K Ohno; K Yamamoto; K Hirakawa Journal: J Neurooncol Date: 2001-03 Impact factor: 4.130
Authors: Alexandra Garancher; Hiromichi Suzuki; Svasti Haricharan; Lianne Q Chau; Meher Beigi Masihi; Jessica M Rusert; Paula S Norris; Florent Carrette; Megan M Romero; Sorana A Morrissy; Patryk Skowron; Florence M G Cavalli; Hamza Farooq; Vijay Ramaswamy; Steven J M Jones; Richard A Moore; Andrew J Mungall; Yussanne Ma; Nina Thiessen; Yisu Li; Alaide Morcavallo; Lin Qi; Mari Kogiso; Yuchen Du; Patricia Baxter; Jacob J Henderson; John R Crawford; Michael L Levy; James M Olson; Yoon-Jae Cho; Aniruddha J Deshpande; Xiao-Nan Li; Louis Chesler; Marco A Marra; Harald Wajant; Oren J Becher; Linda M Bradley; Carl F Ware; Michael D Taylor; Robert J Wechsler-Reya Journal: Nat Neurosci Date: 2020-05-18 Impact factor: 24.884