Literature DB >> 8229033

Intermittent high-dose vitamin C therapy in patients with HTLV-I associated myelopathy.

A Kataoka1, H Imai, S Inayoshi, T Tsuda.   

Abstract

The efficacy of intermittent high-dose vitamin C therapy was evaluated in seven patients with HTLV-I-associated myelopathy (HAM). All HAM patients responded well to this therapy without serious side effects. Grade of disability score improved at 9.7 (SD 5.8) months after the therapy from 7.1 (3.3) to 3.6 (2.0) (p < 0.01). Serum immunosuppressive acidic protein was elevated before and decreased after the therapy from 747 (316) to 398 (86) micrograms/ml (p < 0.05), suggesting favourable immunomodulatory action of vitamin C therapy in HAM patients.

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Year:  1993        PMID： 8229033      PMCID： PMC489823          DOI： 10.1136/jnnp.56.11.1213

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  13 in total

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Authors:  K Arimura; R Rosales; M Osame; A Igata
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Journal:  J Immunol       Date:  1979-11       Impact factor: 5.422

3.  Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells.

Authors:  S Harakeh; R J Jariwalla; L Pauling
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

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Journal:  Am J Clin Nutr       Date:  1977-07       Impact factor: 7.045

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Authors:  R F Cathcart
Journal:  Med Hypotheses       Date:  1984-08       Impact factor: 1.538

6.  In vitro modulation of lymphocyte proliferation by prednisolone and interferon-alpha in patients with HTLV-I-associated myelopathy (HAM).

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Journal:  J Neuroimmunol       Date:  1989-07       Impact factor: 3.478

7.  Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom.

Authors:  J K Cruickshank; P Rudge; A G Dalgleish; M Newton; B N McLean; R O Barnard; B E Kendall; D H Miller
Journal:  Brain       Date:  1989-08       Impact factor: 13.501

8.  Significant increase in immunosuppressive acidic protein (IAP) in serum of patients with multiple sclerosis and other inflammatory neurological disorders.

Authors:  T Tsukamoto; H Seki; S Takase; T Sekizawa; S Nakamura
Journal:  J Neurol Sci       Date:  1986-10       Impact factor: 3.181

9.  Intrathecal synthesis of immunosuppressive acidic protein (IAP) in patients with multiple sclerosis and other inflammatory neurological diseases.

Authors:  H Seki; T Tsukamoto; H Aso; K Tamura
Journal:  J Neurol Sci       Date:  1988-07       Impact factor: 3.181

10.  Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV-I-associated myelopathy.

Authors:  Y Itoyama; S Minato; J Kira; I Goto; H Sato; K Okochi; N Yamamoto
Journal:  Neurology       Date:  1988-08       Impact factor: 9.910
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Authors:  R E Beyer
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Review 6.  The protective role of vitamin C in the management of COVID-19: A Review.

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7.  Therapeutic benefits of an oral vitamin B1 derivative for human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

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8.  Effect of Pulsed Methylprednisolone on Pain, in Patients with HTLV-1-Associated Myelopathy.

Authors:  Kevin G Buell; Aiysha Puri; Maria Antonietta Demontis; Charlotte L Short; Adine Adonis; Jana Haddow; Fabiola Martin; Divya Dhasmana; Graham P Taylor
Journal:  PLoS One       Date:  2016-04-14       Impact factor: 3.240
  8 in total

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