Literature DB >> 8229016

Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile.

K Likhitwitayawuid1, C K Angerhofer, H Chai, J M Pezzuto, G A Cordell, N Ruangrungsi.   

Abstract

From the bulbs of Crinum amabile (Amaryllidaceae), a new alkaloid (-)-amabiline [1], together with the known alkaloids (-)-lycorine [2], (-)-buphanisine [3], (-)-augustine [4], and (+)-crinamine [5], were isolated. The structural characterization of 1 and the revised 1H- and 13C-nmr assignments of 2 are discussed. Alkaloids 2, 4, and 5 were found to be the principal cytotoxic and antimalarial constituents.

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Year:  1993        PMID: 8229016     DOI: 10.1021/np50098a017

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  18 in total

1.  Trichomonas vaginalis NTPDase inhibited by lycorine modulates the parasite-neutrophil interaction.

Authors:  Brenda Petró-Silveira; Graziela Vargas Rigo; Danielle da Silva Trentin; Alexandre José Macedo; Elisa Sauer; Elen de Oliveira Alves; Luciana Ruschel Tallini; Solange Cristina Garcia; Warley de Souza Borges; José Ângelo Silveira Zuanazzi; Tiana Tasca
Journal:  Parasitol Res       Date:  2020-06-11       Impact factor: 2.289

2.  Two novel ceramides with a phytosphingolipid and a tertiary amide structure from Zephyranthes candida.

Authors:  Zhi-Ping Wu; Yu Chen; Bing Xia; Ming Wang; Yun-Fa Dong; Xu Feng
Journal:  Lipids       Date:  2008-10-22       Impact factor: 1.880

3.  Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.

Authors:  Laura Casu; Filippo Cottiglia; Marco Leonti; Alessandro De Logu; Emanuela Agus; Yuk-Ching Tse-Dinh; Valentina Lombardo; Claudia Sissi
Journal:  Bioorg Med Chem Lett       Date:  2011-10-01       Impact factor: 2.823

4.  Bulbispermine: a crinine-type Amaryllidaceae alkaloid exhibiting cytostatic activity toward apoptosis-resistant glioma cells.

Authors:  Giovanni Luchetti; Robert Johnston; Véronique Mathieu; Florence Lefranc; Kathryn Hayden; Anna Andolfi; Delphine Lamoral-Theys; Mary R Reisenauer; Cody Champion; Stephen C Pelly; Willem A L van Otterlo; Igor V Magedov; Robert Kiss; Antonio Evidente; Snezna Rogelj; Alexander Kornienko
Journal:  ChemMedChem       Date:  2012-03-02       Impact factor: 3.466

5.  Enantioselective total synthesis of (+)-amabiline.

Authors:  Timothy J Senter; Olugbeminiyi O Fadeyi; Craig W Lindsley
Journal:  Org Lett       Date:  2012-03-20       Impact factor: 6.005

6.  Selective cytotoxic activities of two novel synthetic drugs on human breast carcinoma MCF-7 cells.

Authors:  Ramesh B Badisa; Selina F Darling-Reed; Patrick Joseph; John S Cooperwood; Lekan M Latinwo; Carl B Goodman
Journal:  Anticancer Res       Date:  2009-08       Impact factor: 2.480

Review 7.  Chemical and biological aspects of Narcissus alkaloids.

Authors:  Jaume Bastida; Rodolfo Lavilla; Francesc Viladomat
Journal:  Alkaloids Chem Biol       Date:  2006

8.  Revised NMR data for incartine: an alkaloid from Galanthus elwesii.

Authors:  Strahil Berkov; Ricardo Reyes-Chilpa; Carles Codina; Francesc Viladomat; Jaume Bastida
Journal:  Molecules       Date:  2007-07-12       Impact factor: 4.411

9.  5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells.

Authors:  Sean Henry; Ria Kidner; Mary R Reisenauer; Igor V Magedov; Robert Kiss; Véronique Mathieu; Florence Lefranc; Ramesh Dasari; Antonio Evidente; Xiaojie Yu; Xiuye Ma; Alexander Pertsemlidis; Regina Cencic; Jerry Pelletier; David A Cavazos; Andrew J Brenner; Alexander V Aksenov; Snezna Rogelj; Alexander Kornienko; Liliya V Frolova
Journal:  Eur J Med Chem       Date:  2016-05-06       Impact factor: 6.514

Review 10.  Towards a molecular understanding of the biosynthesis of amaryllidaceae alkaloids in support of their expanding medical use.

Authors:  Adam M Takos; Fred Rook
Journal:  Int J Mol Sci       Date:  2013-05-31       Impact factor: 5.923

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