Literature DB >> 8228684

Deficiencies in the National Institute of Health's guidelines for the care and protection of laboratory animals.

W Stephenson1.   

Abstract

This paper is a critique of NIH guidelines for the care and protection of laboratory animals. It exposes four serious deficiencies in these guidelines: (1) failure to make it clear that the mere pursuit of knowledge does not justify using animals; (2) failure to give any guidance concerning what constitutes human benefit or well-being; (3) failure to countenance trade-offs between human benefit or well-being and animal well-being; (4) failure to clearly specify what constitutes keeping animals in an 'environment appropriate to the species and its life history.' It concludes with the suggestion that the construction and revision of these guidelines is too important to be left to the professionals.

Entities:  

Keywords:  Biomedical and Behavioral Research; Guide for the Care and Use of Laboratory Animals (National Research Council); NIH Guidelines; National Institutes of Health; Oregon Regional Primate Research Center

Mesh:

Year:  1993        PMID: 8228684     DOI: 10.1093/jmp/18.4.375

Source DB:  PubMed          Journal:  J Med Philos        ISSN: 0360-5310


  5 in total

1.  Ketamine administration ameliorates anesthesia and surgery-induced cognitive dysfunction via activation of TRPV4 channel opening.

Authors:  Qi Li; Dong-Na Zhou; Yi-Qing Tu; Xin-Wei Wu; Da-Qing Pei; Yun Xiong
Journal:  Exp Ther Med       Date:  2022-06-01       Impact factor: 2.751

2.  Decision Making and the IACUC: Part 1- Protocol Information Discussed at Full-Committee Reviews.

Authors:  Jerald Silverman; Charles W Lidz; Jonathan C Clayfield; Alexandra Murray; Lorna J Simon; Richard G Rondeau
Journal:  J Am Assoc Lab Anim Sci       Date:  2015-07       Impact factor: 1.232

3.  Intrathecal injection of fluorocitric acid inhibits the activation of glial cells causing reduced mirror pain in rats.

Authors:  Jing Cao; Zhihua Li; Zhenhua Zhang; Xiuhua Ren; Qingzan Zhao; Jinping Shao; Ming Li; Jiannan Wang; Puchao Huang; Weidong Zang
Journal:  BMC Anesthesiol       Date:  2014-12-15       Impact factor: 2.217

4.  Effect of inhibiting ACAT-1 expression on the growth and metastasis of Lewis lung carcinoma.

Authors:  Minghong Bi; Xuxu Qiao; Haoran Zhang; Huazhang Wu; Zhenyuan Gao; Hairong Zhou; Mohan Shi; Yaping Wang; Jingru Yang; Jianguo Hu; Weichen Liang; Yonghong Liu; Xujie Qiao; Shanshan Zhang; Zhibiao Zhao
Journal:  Oncol Lett       Date:  2019-05-31       Impact factor: 2.967

5.  Downregulation of G‑protein‑coupled receptor 30 in the hippocampus attenuates the neuroprotection of estrogen in the critical period hypothesis.

Authors:  Yingxi Wu; Dayun Feng; Jiaji Lin; Yan Qu; Shiming He; Yuan Wang; Guodong Gao; Tianzhi Zhao
Journal:  Mol Med Rep       Date:  2018-02-16       Impact factor: 2.952

  5 in total

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