Literature DB >> 8226277

Synergistic effect of radiation on colon carcinogenesis induced by methylazoxymethanol acetate in ACI/N rats.

T Tanaka1, Y Morishita, T Kawamori, M Suzui, T Kojima, S Sugie, H Mori.   

Abstract

The effect on colon and liver carcinogenicity in rats of a single X-irradiation exposure given either before or after methylazoxymethanol (MAM) acetate was studied in ACI/N rats of both sexes. A single dose of X-irradiation (3 Gy) was administered either 3 months before or after three weekly s.c. injections of MAM acetate (25 mg/kg body weight). At 365 days after the start, the incidence and multiplicity of MAM acetate-induced intestinal tumors were enhanced by X-irradiation either prior to or after the MAM acetate treatment. In addition, X-irradiation before MAM acetate increased the incidence of hepatocellular foci in either sex. In females, X-irradiation either before or after MAM acetate exposure decreased intestinal tumorigenesis. These findings suggest an apparent synergism of these agents in intestinal carcinogenesis of male rats.

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Year:  1993        PMID： 8226277      PMCID： PMC5919053          DOI： 10.1111/j.1349-7006.1993.tb02797.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


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