Literature DB >> 8226275

Primary gastric carcinoma cells frequently lose heterozygosity at the APC and MCC genetic loci.

G Tamura1, C Maesawa, Y Suzuki, S Ogasawara, M Terashima, K Saito, R Satodate.   

Abstract

Loss of heterozygosity (LOH) at APC and MCC gene loci (both mapped to 5q21) was investigated in 24 surgical specimens of primary gastric carcinomas using the polymerase chain reaction after tumor cell enrichment by cell sorting based on differences in DNA content. LOH at APC and/or MCC was detected in 87% (13/15) of the cases; at the APC in 86% (12/14) and at the MCC locus in 100% (7/7). LOH at the APC locus was always accompanied by LOH at the MCC locus. LOH at the APC and/or MCC was found in both differentiated and undifferentiated types in both early and advanced stages of gastric carcinoma. Thus, LOH at APC and/or MCC is considered to be one of the most prevalent genetic alterations in human gastric carcinoma and occurs at an early stage of the carcinogenesis.

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Mesh：

Year:  1993        PMID： 8226275      PMCID： PMC5919060          DOI： 10.1111/j.1349-7006.1993.tb02794.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  19 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205

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Journal:  Cell       Date:  1991-08-09       Impact factor: 41.582

3.  Mutations in the p53 gene occur in diverse human tumour types.

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Journal:  Nature       Date:  1989-12-07       Impact factor: 49.962

Review 4.  Genetic alterations in human gastric cancer.

Authors:  S Hirohashi; T Sugimura
Journal:  Cancer Cells       Date:  1991-02

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Journal:  Science       Date:  1991-03-15       Impact factor: 47.728

6.  Frequent somatic mutations of the APC gene in human pancreatic cancer.

Authors:  A Horii; S Nakatsuru; Y Miyoshi; S Ichii; H Nagase; H Ando; A Yanagisawa; E Tsuchiya; Y Kato; Y Nakamura
Journal:  Cancer Res       Date:  1992-12-01       Impact factor: 12.701

7.  Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis.

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Journal:  Cancer Res       Date:  1992-02-01       Impact factor: 12.701

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Authors:  E Tahara
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

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Authors:  A Horii; S Nakatsuru; Y Miyoshi; S Ichii; H Nagase; Y Kato; A Yanagisawa; Y Nakamura
Journal:  Cancer Res       Date:  1992-06-01       Impact factor: 12.701

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Authors:  G C Burmer; L A Loeb
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205
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  13 in total

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Authors:  Zhengyu Fang; Yi Xiong; Jiana Li; Li Liu; Wei Zhang; Chao Zhang; Jun Wan
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Journal:  Am J Pathol       Date:  2001-06       Impact factor: 4.307

3.  Infrequent loss of heterozygosity of APC/MCC and DCC genes in gastric cancer showing DNA microsatellite instability.

Authors:  D C Fang; J R Jass; D X Wang; X D Zhou; Y H Luo; J Young
Journal:  J Clin Pathol       Date:  1999-07       Impact factor: 3.411

4.  Analysis of genetic alterations in renal cell carcinoma using the polymerase chain reaction.

Authors:  Y Suzuki; G Tamura; C Maesawa; T Fujioka; T Kubo; R Satodate
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

5.  Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas.

Authors:  S Ogasawara; C Maesawa; G Tamura; R Satodate
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

6.  Aberrations of the APC gene in primary breast carcinoma.

Authors:  M Kashiwaba; G Tamura; M Ishida
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

7.  Allelotype analysis of adenocarcinoma of the gastric cardia.

Authors:  C M Gleeson; J M Sloan; J A McGuigan; A J Ritchie; J L Weber; S E Russell
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

8.  Correlation between the methylation of APC gene promoter and colon cancer.

Authors:  Bing-Qiang Li; Peng-Peng Liu; Cai-Hua Zhang
Journal:  Oncol Lett       Date:  2017-06-21       Impact factor: 2.967

9.  Novel APC gene mutations associated with protein alteration in diffuse type gastric cancer.

Authors:  Souvik Ghatak; Payel Chakraborty; Sandeep Roy Sarkar; Biswajit Chowdhury; Arup Bhaumik; Nachimuthu Senthil Kumar
Journal:  BMC Med Genet       Date:  2017-06-02       Impact factor: 2.103

10.  Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.

Authors:  R Sud; I C Talbot; J D Delhanty
Journal:  Br J Cancer       Date:  1996-10       Impact factor: 7.640
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