Literature DB >> 8224921

Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2.

M Kurabayashi1, R Jeyaseelan, L Kedes.   

Abstract

Two distinct Id2 cDNA clones, Id2A and Id2B (inhibitor of differentiation), have been isolated from a human heart cDNA library and sequenced. The deduced amino acid sequences show nearly complete identity, except for the nonsense mutation at codon 37 in Id2B. Characterization of the genomic clones revealed that Id2B is encoded by an intronless gene which probably arose after the evolutionary divergence of rats and humans.

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Year:  1993        PMID： 8224921     DOI： 10.1016/0378-1119(93)90658-p

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  7 in total

Review 1.  Helix-loop-helix proteins in mammary gland development and breast cancer.

Authors:  Pierre-Yves Desprez; Tomoki Sumida; Jean-Philippe Coppé
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-04       Impact factor: 2.673

2.  Inhibition of muscle-specific gene expression by Id3: requirement of the C-terminal region of the protein for stable expression and function.

Authors:  B Chen; B H Han; X H Sun; R W Lim
Journal:  Nucleic Acids Res       Date:  1997-01-15       Impact factor: 16.971

3.  Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes.

Authors:  M Moldes; M Boizard; X L Liepvre; B Fève; I Dugail; J Pairault
Journal:  Biochem J       Date:  1999-12-15       Impact factor: 3.857

4.  E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice.

Authors:  M A Shield; H S Haugen; C H Clegg; S D Hauschka
Journal:  Mol Cell Biol       Date:  1996-09       Impact factor: 4.272

5.  Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas.

Authors:  Michael D Onken; Justis P Ehlers; Lori A Worley; Jun Makita; Yoshifumi Yokota; J William Harbour
Journal:  Cancer Res       Date:  2006-05-01       Impact factor: 12.701

6.  Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors.

Authors:  M Florio; M C Hernandez; H Yang; H K Shu; J L Cleveland; M A Israel
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272

7.  Doxorubicin-induced Id2A gene transcription is targeted at an activating transcription factor/cyclic AMP response element motif through novel mechanisms involving protein kinases distinct from protein kinase C and protein kinase A.

Authors:  M Kurabayashi; S Dutta; R Jeyaseelan; L Kedes
Journal:  Mol Cell Biol       Date:  1995-11       Impact factor: 4.272
  7 in total

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