Literature DB >> 8224803

Improved sib-pair linkage test for disease susceptibility loci.

J J Faraway1.   

Abstract

An improved sib-pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi-squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact power comparisons are made with the previously proposed tests. The new test is shown to be more powerful for finite samples as well as being asymptotically uniformly most powerful.

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Year:  1993        PMID： 8224803     DOI： 10.1002/gepi.1370100403

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  6 in total

1.  All LODs are not created equal.

Authors:  D R Nyholt
Journal:  Am J Hum Genet       Date:  2000-07-06       Impact factor: 11.025

Review 2.  Linkage analysis in the next-generation sequencing era.

Authors:  Joan E Bailey-Wilson; Alexander F Wilson
Journal:  Hum Hered       Date:  2011-12-23       Impact factor: 0.444

3.  Two-locus disease models with two marker loci: the power of affected-sib-pair tests.

Authors:  M Knapp; S A Seuchter; M P Baur
Journal:  Am J Hum Genet       Date:  1994-11       Impact factor: 11.025

4.  Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.

Authors:  Joseph H Lee; Rong Cheng; Ekaterina Rogaeva; Yan Meng; Yaakov Stern; Vincent Santana; Rafael Lantigua; Martin Medrano; Ivonne Z Jimenez-Velazquez; Lindsay A Farrer; Peter St George-Hyslop; Richard Mayeux
Journal:  Neurogenetics       Date:  2008-03-14       Impact factor: 2.660

5.  A genomewide screen of 345 families for autism-susceptibility loci.

Authors:  Amanda L Yonan; Maricela Alarcón; Rong Cheng; Patrik K E Magnusson; Sarah J Spence; Abraham A Palmer; Adina Grunn; Suh-Hang Hank Juo; Joseph D Terwilliger; Jianjun Liu; Rita M Cantor; Daniel H Geschwind; T Conrad Gilliam
Journal:  Am J Hum Genet       Date:  2003-09-17       Impact factor: 11.025

6.  A genomewide screen for autism susceptibility loci.

Authors:  J Liu; D R Nyholt; P Magnussen; E Parano; P Pavone; D Geschwind; C Lord; P Iversen; J Hoh; J Ott; T C Gilliam
Journal:  Am J Hum Genet       Date:  2001-07-10       Impact factor: 11.025
  6 in total

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