Literature DB >> 822279

Nucleoside auxotrophy in Drosophila: an autosomal locus yielding mutants supplementable by purine and pyrimidine ribonucleosides.

F N Naguib, D Nash.   

Abstract

Two allelic auxotrophic mutants at a locus close to the bw locus (2-104.5) of Drosophila melanogaster are described. The mutants respond to dietary ribonucleosides (uridine, cytidine, adenosine, guanosine and inosine) but less well to bases or pyrimidine precursors. This phenotype is unique to these mutants. We suggest that the mutants are defective in phosphoribosyl pyrophosphate biosynthesis.

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Year:  1976        PMID： 822279     DOI： 10.1007/BF00337930

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  14 in total

1.  Studies on female-sterility genes in Drosophila melanogaster. III. The effects of the gene rudimentary on embryonic development.

Authors:  S J COUNCE
Journal:  Z Indukt Abstamm Vererbungsl       Date:  1956

2.  Uridylic acid synthesis in Ehrlich ascites carcinoma. Properties, subcellular distribution, and nature of enzyme complexes of the six biosynthetic enzymes.

Authors:  W T Shoaf; M E Jones
Journal:  Biochemistry       Date:  1973-10-09       Impact factor: 3.162

3.  Biology of 5-fluoro-2'-deoxyuridine sensitivity of Drosophila melanogaster larvae.

Authors:  M H el Kouni; D Nash
Journal:  J Insect Physiol       Date:  1974-08       Impact factor: 2.354

4.  Physiological genetics of melanotic tumors in Drosophila melanogaster. VI. The tumorigenic effects of juvenile hormone-like substances.

Authors:  P J Bryant; J H Sang
Journal:  Genetics       Date:  1969-06       Impact factor: 4.562

5.  A complex genetic locus that controls of the first three steps of pyrimidine biosynthesis in Drosophila.

Authors:  J M Rawls; J W Fristrom
Journal:  Nature       Date:  1975-06-26       Impact factor: 49.962

6.  Repair of a genetically-caused defect in oogenesis in Drosophila melanogaster by transplantation of cytoplasm from wild-type eggs and by injection of pyrimidine nucleosides.

Authors:  M Okada; I A Kleinman; H A Schneiderman
Journal:  Dev Biol       Date:  1974-03       Impact factor: 3.582

7.  The biochemical genetics of rudimentary mutants of Drosophila melanogaster. I. Aspartate carbamoyltransferase levels in complementing and non-complementing strains.

Authors:  S Norby
Journal:  Hereditas       Date:  1973       Impact factor: 3.271

8.  Functional diversity within the rudimentary locus of Drosophila melanogaster.

Authors:  B Jarry; D Falk
Journal:  Mol Gen Genet       Date:  1974

9.  A specific nutritional requirement for pyrimidines in rudimentary mutants of Drosophila melanogaster.

Authors:  S Norby
Journal:  Hereditas       Date:  1970       Impact factor: 3.271

10.  Pyrimidine-sensitive drosophila wing mutants: withered (whd), tilt (tt) and dumpy (dp).

Authors:  P Stroman
Journal:  Hereditas       Date:  1974       Impact factor: 3.271
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  4 in total

1.  Genetic analysis of the adenosine3 (Gart) region of the second chromosome of Drosophila melanogaster.

Authors:  S Y Tiong; D Nash
Journal:  Genetics       Date:  1990-04       Impact factor: 4.562

2.  Two Drosophila melanogaster mutations block successive steps of de novo purine synthesis.

Authors:  S Henikoff; D Nash; R Hards; J Bleskan; J F Woolford; F Naguib; D Patterson
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

3.  Three purine auxotrophic loci on the second chromosome of Drosophila melanogaster.

Authors:  M E Johnstone; D Nash; F N Naguib
Journal:  Biochem Genet       Date:  1985-08       Impact factor: 1.890

4.  Cytogenetic localisation of the purine 1 and guanosine 1 loci of Drosophila melanogaster; the purine 1 locus specifies a vital function.

Authors:  M M Johnson; E P Woloshyn; D Nash
Journal:  Mol Gen Genet       Date:  1979-07-24
  4 in total

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