Literature DB >> 8222502

A new calcitonin-receptor-like sequence in rat pulmonary blood vessels.

F Njuki1, C G Nicholl, A Howard, J C Mak, P J Barnes, S I Girgis, S Legon.   

Abstract

1. Two rat clones have been isolated which are similar to known calcitonin-receptor sequences. One of these does not have the distribution expected of a calcitonin receptor. It is widely distributed, with extremely high levels of expression in the lung, where it is associated with the blood vessels. 2. This rat sequence may represent the receptor for calcitonin-gene-related peptide or islet amyloid polypeptide. Both have binding activity in the lung and are potent vasodilators. The gene represented by this sequence may therefore play an important role in the maintenance of vascular tone.

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Year:  1993        PMID： 8222502     DOI： 10.1042/cs0850385

Source DB:  PubMed          Journal:  Clin Sci (Lond)        ISSN： 0143-5221            Impact factor:   6.124


  20 in total

1.  CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) in rat tissues.

Authors:  P Chakravarty; T P Suthar; H A Coppock; C G Nicholl; S R Bloom; S Legon; D M Smith
Journal:  Br J Pharmacol       Date:  2000-05       Impact factor: 8.739

2.  Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes.

Authors:  R J Bailey; C S Walker; A H Ferner; K M Loomes; G Prijic; A Halim; L Whiting; A R J Phillips; D L Hay
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

3.  Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity.

Authors:  H A Coppock; A A Owji; C Austin; P D Upton; M L Jackson; J V Gardiner; M A Ghatei; S R Bloom; D M Smith
Journal:  Biochem J       Date:  1999-02-15       Impact factor: 3.857

Review 4.  Chaperoning G protein-coupled receptors: from cell biology to therapeutics.

Authors:  Ya-Xiong Tao; P Michael Conn
Journal:  Endocr Rev       Date:  2014-03-24       Impact factor: 19.871

5.  Quinoline derivatives: candidate drugs for a class B G-protein coupled receptor, the calcitonin gene-related peptide receptor, a cause of migraines.

Authors:  Hira Iftikhar; Iqra Ahmad; Siew H Gan; Munvar M Shaik; Naveed Iftikhar; Muhammad S Nawaz; Nigel H Greig; Mohammad A Kamal
Journal:  CNS Neurol Disord Drug Targets       Date:  2014       Impact factor: 4.388

6.  CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS.

Authors:  D L Hay; S G Howitt; A C Conner; M Schindler; D M Smith; D R Poyner
Journal:  Br J Pharmacol       Date:  2003-08-26       Impact factor: 8.739

7.  Calcitonin-gene-related peptide stimulates stromal cell osteogenic differentiation and inhibits RANKL induced NF-kappaB activation, osteoclastogenesis and bone resorption.

Authors:  Liping Wang; Xiaoyou Shi; Rong Zhao; Bernard P Halloran; David J Clark; Christopher R Jacobs; Wade S Kingery
Journal:  Bone       Date:  2009-12-02       Impact factor: 4.398

8.  Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene.

Authors:  Ryan T Dackor; Kimberly Fritz-Six; William P Dunworth; Carrie L Gibbons; Oliver Smithies; Kathleen M Caron
Journal:  Mol Cell Biol       Date:  2006-04       Impact factor: 4.272

Review 9.  The expanding repertoire of receptor activity modifying protein (RAMP) function.

Authors:  Klara R Klein; Brooke C Matson; Kathleen M Caron
Journal:  Crit Rev Biochem Mol Biol       Date:  2016-01-06       Impact factor: 8.250

10.  Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.

Authors:  Philip S Miller; James Barwell; David R Poyner; Mark J Wigglesworth; Stephen L Garland; Dan Donnelly
Journal:  Biochem Biophys Res Commun       Date:  2009-11-13       Impact factor: 3.575
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