Literature DB >> 8221118

Antibodies to quinolinic acid reveal localization in select immune cells rather than neurons or astroglia.

J R Moffett1, M G Espey, S J Gaudet, M A Namboodiri.   

Abstract

Polyclonal antibodies were produced against quinolinic acid. No immunoreactivity was observed in any cell type in carbodiimide-fixed brain tissue from control rats. When the antibodies were applied to carbodiimide-fixed spleen tissue, strong quinolinic acid immunoreactivity was observed in some cells with the appearance of macrophages and dendritic cells. These findings indicate an immune system origin for quinolinic acid, and implicate immune cells in excitotoxic CNS pathologies. These findings also raise the possibility that quinolinic acid is a unique cytokine in immune system signal transmission.

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Year:  1993        PMID： 8221118     DOI： 10.1016/0006-8993(93)91450-7

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  Excitotoxicity of quinolinic acid: modulation by endogenous antagonists.

Authors:  K H Jhamandas; R J Boegman; R J Beninger; A F Miranda; K A Lipic
Journal:  Neurotox Res       Date:  2000       Impact factor: 3.911

2.  Kynurenine pathway metabolites in humans: disease and healthy States.

Authors:  Yiquan Chen; Gilles J Guillemin
Journal:  Int J Tryptophan Res       Date:  2009-01-08

Review 3.  Unbalanced IDO1/IDO2 Endothelial Expression and Skewed Keynurenine Pathway in the Pathogenesis of COVID-19 and Post-COVID-19 Pneumonia.

Authors:  Marco Chilosi; Claudio Doglioni; Claudia Ravaglia; Guido Martignoni; Gian Luca Salvagno; Giovanni Pizzolo; Vincenzo Bronte; Venerino Poletti
Journal:  Biomedicines       Date:  2022-06-06

Review 4.  Tryptophan, adenosine, neurodegeneration and neuroprotection.

Authors:  T W Stone; C M Forrest; G M Mackay; N Stoy; L G Darlington
Journal:  Metab Brain Dis       Date:  2007-12       Impact factor: 3.584

5.  Immunocytochemical localization of the endogenous neuroexcitotoxin quinolinate in human peripheral blood monocytes/macrophages and the effect of human T-cell lymphotropic virus type I infection.

Authors:  C N Venkateshan; R Narayanan; M G Espey; J R Moffett; D C Gajdusek; C J Gibbs; M A Namboodiri
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-20       Impact factor: 11.205

6.  Antibodies to quinolinic acid and the determination of its cellular distribution within the rat immune system.

Authors:  J R Moffett; M G Espey; M A Namboodiri
Journal:  Cell Tissue Res       Date:  1994-12       Impact factor: 5.249

Review 7.  The end of the road for the tryptophan depletion concept in pregnancy and infection.

Authors:  Abdulla A-B Badawy; Aryan M A Namboodiri; John R Moffett
Journal:  Clin Sci (Lond)       Date:  2016-08-01       Impact factor: 6.124

8.  Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina.

Authors:  Ping Hu; Nicholas H Hunt; Frank Arfuso; Lynn C Shaw; Mohammad Nasir Uddin; Meidong Zhu; Raj Devasahayam; Samuel J Adamson; Vicky L Benson; Tailoi Chan-Ling; Maria B Grant
Journal:  Invest Ophthalmol Vis Sci       Date:  2017-10-01       Impact factor: 4.799

9.  Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD+ Synthesis During Inflammation and Infection.

Authors:  John R Moffett; Peethambaran Arun; Narayanan Puthillathu; Ranjini Vengilote; John A Ives; Abdulla A-B Badawy; Aryan M Namboodiri
Journal:  Front Immunol       Date:  2020-02-21       Impact factor: 7.561
  9 in total

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