| Literature DB >> 8221116 |
S F Maier1, E P Wiertelak, D Martin, L R Watkins.
Abstract
The sickness-inducing agents lithium chloride (LiCl) and lipopolysaccharide (LPS) produce a long-lasting facilitation of the nociceptive tailflick reflex. Many of the behavioral and physiological changes produced by illness are mediated by interleukin-1 (IL-1) released from monocytes stimulated by the pathogenic substance. Monocytes also produce an IL-1 receptor antagonist (IL-1ra) which has been sequenced and cloned. The present experiments report that IL-1 can itself produce hyperalgesia as assessed by tailflick to radiant heat, and that recombinant IL-1ra blocks the hyperalgesia produced by LiCl and LPS.Entities:
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Year: 1993 PMID： 8221116 DOI： 10.1016/0006-8993(93)91446-y
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252