Literature DB >> 8221061

Spinal cord motoneurons express p75NGFR and p145trkB mRNA in amyotrophic lateral sclerosis.

J L Seeburger1, S Tarras, H Natter, J E Springer.   

Abstract

In the present study, in situ hybridization was used to examine the expression of nerve growth factor (NGF) receptor (p75NGFR), trk (p140trk) and trkB (p145trkB) mRNA in spinal cord sections from patients with amyotrophic lateral sclerosis (ALS). We report that the expression of p75NGFR and p145trkB mRNA is elevated in alpha motoneurons in ALS sections. However, p140trk mRNA was not expressed in either ALS or control sections.

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Year:  1993        PMID： 8221061     DOI： 10.1016/0006-8993(93)90304-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  23 in total

1.  Pro-NGF secreted by astrocytes promotes motor neuron cell death.

Authors:  Marco Domeniconi; Barbara L Hempstead; Moses V Chao
Journal:  Mol Cell Neurosci       Date:  2006-12-26       Impact factor: 4.314

Review 2.  Dynamic nature of the p75 neurotrophin receptor in response to injury and disease.

Authors:  Rick Meeker; Kimberly Williams
Journal:  J Neuroimmune Pharmacol       Date:  2014-09-20       Impact factor: 4.147

Review 3.  The response of motoneurons to neurotrophins.

Authors:  M Sendtner; B Holtmann; R A Hughes
Journal:  Neurochem Res       Date:  1996-07       Impact factor: 3.996

4.  Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75NTR and RAGE Signaling in ALS.

Authors:  Mi Jin Kim; Marcelo R Vargas; Benjamin A Harlan; Kelby M Killoy; Lauren E Ball; Susana Comte-Walters; Monika Gooz; Yasuhiko Yamamoto; Joseph S Beckman; Luis Barbeito; Mariana Pehar
Journal:  Antioxid Redox Signal       Date:  2017-06-26       Impact factor: 8.401

5.  Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues.

Authors:  M Yamamoto; G Sobue; K Yamamoto; S Terao; T Mitsuma
Journal:  Neurochem Res       Date:  1996-08       Impact factor: 3.996

6.  Decreased phosphorylation levels of TrkB neurotrophin receptor in the spinal cords from patients with amyotrophic lateral sclerosis.

Authors:  T Mutoh; G Sobue; T Hamano; M Kuriyama; M Hirayama; M Yamamoto; T Mitsuma
Journal:  Neurochem Res       Date:  2000-02       Impact factor: 3.996

Review 7.  Astrogliosis in amyotrophic lateral sclerosis: role and therapeutic potential of astrocytes.

Authors:  Marcelo R Vargas; Jeffrey A Johnson
Journal:  Neurotherapeutics       Date:  2010-10       Impact factor: 7.620

8.  Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the adult rat spinal cord: regulation by the glutamate receptor agonist kainic acid.

Authors:  I A Scarisbrick; P J Isackson; A J Windebank
Journal:  J Neurosci       Date:  1999-09-15       Impact factor: 6.167

Review 9.  Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS.

Authors:  Derek A Drechsel; Alvaro G Estévez; Luis Barbeito; Joseph S Beckman
Journal:  Neurotox Res       Date:  2012-04-10       Impact factor: 3.911

10.  Continuous brain-derived neurotrophic factor (BDNF) infusion after methylprednisolone treatment in severe spinal cord injury.

Authors:  Daniel H Kim; Tae-Ahn Jahng
Journal:  J Korean Med Sci       Date:  2004-02       Impact factor: 2.153
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