Literature DB >> 8218409

Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65).

D S Lee1, J Tian, T Phan, D L Kaufman.   

Abstract

We report the cloning and cDNA sequence of murine GAD65. Murine GAD65 is comprised of 585 amino acids and shares a high degree of homology with human and rat GAD65, with most divergences occurring near their amino-termini. The murine GAD65 sequence will allow evaluation of the role of this gene in murine neurogenetic and autoimmune diseases.

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Year:  1993        PMID： 8218409     DOI： 10.1016/0167-4781(93)90056-j

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  CCR4-bearing T cells participate in autoimmune diabetes.

Authors:  Soon H Kim; Mary M Cleary; Howard S Fox; David Chantry; Nora Sarvetnick
Journal:  J Clin Invest       Date:  2002-12       Impact factor: 14.808

Review 2.  GAD, diabetes, and Stiff-Man syndrome: some progress and more questions.

Authors:  M Solimena; M H Butler; P De Camilli
Journal:  J Endocrinol Invest       Date:  1994 Jul-Aug       Impact factor: 4.256

3.  Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

Authors:  L S Wicker; S L Chen; G T Nepom; J F Elliott; D C Freed; A Bansal; S Zheng; A Herman; A Lernmark; D M Zaller; L B Peterson; J B Rothbard; R Cummings; P J Whiteley
Journal:  J Clin Invest       Date:  1996-12-01       Impact factor: 14.808

4.  Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice.

Authors:  L Wen; F S Wong; L Burkly; M Altieri; C Mamalaki; D Kioussis; R A Flavell; R S Sherwin
Journal:  J Clin Invest       Date:  1998-09-01       Impact factor: 14.808

5.  HLA-DR-restricted T cell lines from newly diagnosed type 1 diabetic patients specific for insulinoma and normal islet beta cell proteins: lack of reactivity to glutamic acid decarboxylase.

Authors:  G C Huang; J Tremble; E Bailyes; S D Arden; T Kaye; A M McGregor; J P Banga
Journal:  Clin Exp Immunol       Date:  1995-10       Impact factor: 4.330

6.  Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.

Authors:  D L Kaufman; M Clare-Salzler; J Tian; T Forsthuber; G S Ting; P Robinson; M A Atkinson; E E Sercarz; A J Tobin; P V Lehmann
Journal:  Nature       Date:  1993-11-04       Impact factor: 49.962

7.  Inhalation of glutamic acid decarboxylase 65-derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non-obese diabetic mouse.

Authors:  R Ravanan; S F Wong; N G Morgan; P W Mathieson; R M Smith
Journal:  Clin Exp Immunol       Date:  2007-05       Impact factor: 4.330

8.  Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

Authors:  J Tian; M A Atkinson; M Clare-Salzler; A Herschenfeld; T Forsthuber; P V Lehmann; D L Kaufman
Journal:  J Exp Med       Date:  1996-04-01       Impact factor: 14.307

9.  T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.

Authors:  J Tian; P V Lehmann; D L Kaufman
Journal:  J Exp Med       Date:  1994-11-01       Impact factor: 14.307
  9 in total

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