OBJECTIVE: To determine prevalence, clinical association and predictive power of antiphospholipid antibodies in pregnancy. DESIGN: To test for the presence of anticardiolipin antibodies and lupus anticoagulant in order to confirm prevalence data which imply that each antibody has the same clinical significance. A detailed obstetric history and the outcome measures were obtained from each patient in the study. SETTING: National Women's Hospital, Auckland, New Zealand. SUBJECTS: Nine hundred and thirty-three consecutively booked pregnant women. MAIN OUTCOME MEASURES: Prevalence of auto-antibodies; perinatal morbidity and mortality; incidence of pre-eclampsia, growth retardation and fetal distress. RESULTS: Nine women (1.0%) had anticardiolipin antibodies, 11 (1.2%) had lupus anticoagulant and two had both antibodies. The fetal mortality rate for women with antibodies was 167/1000. Pre-eclampsia occurred significantly more often in women with auto-antibodies. CONCLUSION: The presence of antiphospholipid antibodies is frequently associated with adverse pregnancy outcome (9/18 pregnancies). High titre anticardiolipin antibodies carry a poor prognosis.
OBJECTIVE: To determine prevalence, clinical association and predictive power of antiphospholipid antibodies in pregnancy. DESIGN: To test for the presence of anticardiolipin antibodies and lupus anticoagulant in order to confirm prevalence data which imply that each antibody has the same clinical significance. A detailed obstetric history and the outcome measures were obtained from each patient in the study. SETTING: National Women's Hospital, Auckland, New Zealand. SUBJECTS: Nine hundred and thirty-three consecutively booked pregnant women. MAIN OUTCOME MEASURES: Prevalence of auto-antibodies; perinatal morbidity and mortality; incidence of pre-eclampsia, growth retardation and fetal distress. RESULTS: Nine women (1.0%) had anticardiolipin antibodies, 11 (1.2%) had lupus anticoagulant and two had both antibodies. The fetal mortality rate for women with antibodies was 167/1000. Pre-eclampsia occurred significantly more often in women with auto-antibodies. CONCLUSION: The presence of antiphospholipid antibodies is frequently associated with adverse pregnancy outcome (9/18 pregnancies). High titre anticardiolipin antibodies carry a poor prognosis.
Authors: Fosca A F Di Prima; Oriana Valenti; Entela Hyseni; Elsa Giorgio; Marianna Faraci; Eliana Renda; Roberta De Domenico; Santo Monte Journal: J Prenat Med Date: 2011-04
Authors: Nir Melamed; Ahmet Baschat; Yoav Yinon; Apostolos Athanasiadis; Federico Mecacci; Francesc Figueras; Vincenzo Berghella; Amala Nazareth; Muna Tahlak; H David McIntyre; Fabrício Da Silva Costa; Anne B Kihara; Eran Hadar; Fionnuala McAuliffe; Mark Hanson; Ronald C Ma; Rachel Gooden; Eyal Sheiner; Anil Kapur; Hema Divakar; Diogo Ayres-de-Campos; Liran Hiersch; Liona C Poon; John Kingdom; Roberto Romero; Moshe Hod Journal: Int J Gynaecol Obstet Date: 2021-03 Impact factor: 3.561
Authors: E Austin-Ward; S Castillo; M Cuchacovich; A Espinoza; J Cofré-Beca; S González; X Solivelles; J Bloomfield Journal: J Med Genet Date: 1998-08 Impact factor: 6.318
Authors: Robert M Silver; Michael W Varner; Uma Reddy; Robert Goldenberg; Halit Pinar; Deborah Conway; Radek Bukowski; Marshall Carpenter; Carol Hogue; Marian Willinger; Donald Dudley; George Saade; Barbara Stoll Journal: Am J Obstet Gynecol Date: 2007-05 Impact factor: 8.661