Literature DB >> 8217057

Effect of diazepam on muscle weakness in a model of myasthenia gravis in rats.

P C Molenaar1, G T Van Kempen.   

Abstract

Rats chronically received alpha-bungarotoxin which caused a reduction of nicotinic acetylcholine receptors and weakness, especially of lip muscles. It was found that diazepam (0.75-2 mg kg-1, s.c.), after a 15 min period of excitation and increased lip weakness, caused sedation and some improvement of the lip. Even after 5 mg kg-1 diazepam, muscle function was not markedly affected and breathing appeared normal. It is concluded that sedation in rats by diazepam does not entail aggravation of the muscle weakness caused by a partial neuromuscular block.

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Year:  1993        PMID： 8217057     DOI： 10.1007/bf01244995

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  9 in total

1.  The influence of diazepam on the dosage of muscel-relaxants during anaesthesia.

Authors:  H F Martins
Journal:  Anaesthesist       Date:  1975-01       Impact factor: 1.041

2.  [The jitter-phenomenon in myasthenia gravis and the influence of diazepame. An electromyographic study of single muscle fibre (author's transl)].

Authors:  I Milonas; D Kountouris; E Müller
Journal:  EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb       Date:  1981-12

Review 3.  Immunology of acetylcholine receptors in relation to myasthenia gravis.

Authors:  A Vincent
Journal:  Physiol Rev       Date:  1980-07       Impact factor: 37.312

4.  Effect of ephedrine on muscle weakness in a model of myasthenia gravis in rats.

Authors:  P C Molenaar; J E Biewenga; G T Van Kempen; J A De Priester
Journal:  Neuropharmacology       Date:  1993-04       Impact factor: 5.250

5.  Effects of diazepam on succinylcholine-induced myalgia, potassium increase, creatine phosphokinase elevation, and relaxation.

Authors:  M Eisenberg; S Balsley; R L Katz
Journal:  Anesth Analg       Date:  1979 Jul-Aug       Impact factor: 5.108

6.  A non-immunogenic myasthenia gravis model and its application in a study of transsynaptic regulation at the neuromuscular junction.

Authors:  P C Molenaar; B S Oen; J J Plomp; G T Van Kempen; F G Jennekens; L F Hesselmans
Journal:  Eur J Pharmacol       Date:  1991-04-10       Impact factor: 4.432

7.  Adaptation of quantal content to decreased postsynaptic sensitivity at single endplates in alpha-bungarotoxin-treated rats.

Authors:  J J Plomp; G T van Kempen; P C Molenaar
Journal:  J Physiol       Date:  1992-12       Impact factor: 5.182

8.  Differential effects of diazepam on rat hindlimb muscles.

Authors:  M Chua; A F Dulhunty
Journal:  Can J Physiol Pharmacol       Date:  1987-09       Impact factor: 2.273

9.  Acetylcholine in intercostal muscle from myasthenia gravis patients and in rat diaphragm after blockade of acetylcholine receptors.

Authors:  P C Molenaar; R L Polak; R Miledi; S Alema; A Vincent; J Newsom-Davis
Journal:  Prog Brain Res       Date:  1979       Impact factor: 2.453
  9 in total

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