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Literature DB >> 8217052

Hippocampal benzodiazepine receptors in schizophrenia.

Abstract

Benzodiazepine receptor sites were determined by saturable [3H]flunitrazepam binding in hippocampal tissue from schizophrenic and control subjects. No difference in receptor density or affinity between the two groups was observed, indicating that the previously identified GABAergic deficit in the hippocampus in schizophrenia does not apparently lead to up-regulation of these receptor sites. The implications of this finding are discussed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1993 PMID： 8217052 DOI： 10.1007/bf01245344

Source DB: PubMed Journal: J Neural Transm Gen Sect

18 in total

1. Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients.

Authors: F M Benes; J McSparren; E D Bird; J P SanGiovanni; S L Vincent
Journal: Arch Gen Psychiatry Date: 1991-11

2. Prospects for research on schizophrenia. An hypotheses suggesting that there is a defect in the GABA system in schizophrenia.

Authors: E Roberts
Journal: Neurosci Res Program Bull Date: 1972-11

Hippocampal benzodiazepine receptors in schizophrenia.

1. Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients.

2. Prospects for research on schizophrenia. An hypotheses suggesting that there is a defect in the GABA system in schizophrenia.

Review 3. Benzodiazepines in the treatment of schizophrenia: an updated survey.

4. Reduced GABA uptake sites in the temporal lobe in schizophrenia.

Review 5. Schizophrenia: the cellular biology of a functional psychosis.

6. Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia.

7. [3H]nipecotic acid binding to gamma-aminobutyric acid uptake sites in postmortem human brain.

8. Hippocampal influence on amygdala unit activity in awake squirrel monkeys.

9. Studies on neurotransmitter receptor systems in neocortex and hippocampus in senile dementia of the Alzheimer-type.

10. High dose diazepam in schizophrenia.

Review 1. Neuroimaging studies of GABA in schizophrenia: a systematic review with meta-analysis.