Literature DB >> 8216210

Decrease in cerebral inositols in rats and humans.

R A Moats1, Y H Lien, D Filippi, B D Ross.   

Abstract

Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain. The portacaval-shunted rat may therefore be a useful model for the investigation of neurochemical pathways containing myoinositol, which are modulated not only in hepatic encephalopathy but also in diabetes mellitus and Alzheimer's disease.

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Year:  1993        PMID： 8216210      PMCID： PMC1134813          DOI： 10.1042/bj2950015

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  THE BIOSYNTHESIS OF FREE AND PHOSPHATIDE MYO-INOSITOL FROM GLUCOSE BY MAMMALIAN TISSUE SLICES.

Authors:  G HAUSER; V N FINELLI
Journal:  J Biol Chem       Date:  1963-10       Impact factor: 5.157

Review 2.  Clinical tools for the 90s: magnetic resonance spectroscopy and metabolite imaging.

Authors:  B Ross; R Kreis; T Ernst
Journal:  Eur J Radiol       Date:  1992 Mar-Apr       Impact factor: 3.528

3.  Hyperammonaemia causes many of the changes found after portacaval shunting.

Authors:  J Jessy; A M Mans; M R DeJoseph; R A Hawkins
Journal:  Biochem J       Date:  1990-12-01       Impact factor: 3.857

4.  Myo-inositol transport in the central nervous system.

Authors:  R Spector; A V Lorenzo
Journal:  Am J Physiol       Date:  1975-05

5.  Reduced phosphoinositide concentrations in anterior temporal cortex of Alzheimer-diseased brains.

Authors:  C E Stokes; J N Hawthorne
Journal:  J Neurochem       Date:  1987-04       Impact factor: 5.372

6.  Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study.

Authors:  T E Bates; S R Williams; R A Kauppinen; D G Gadian
Journal:  J Neurochem       Date:  1989-07       Impact factor: 5.372

7.  Portacaval anastomosis: brain and plasma metabolite abnormalities and the effect of nutritional therapy.

Authors:  A M Mans; J F Biebuyck; D W Davis; R A Hawkins
Journal:  J Neurochem       Date:  1984-09       Impact factor: 5.372

8.  Effects of hypernatremia on organic brain osmoles.

Authors:  Y H Lien; J I Shapiro; L Chan
Journal:  J Clin Invest       Date:  1990-05       Impact factor: 14.808

9.  Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy.

Authors:  R Kreis; B D Ross; N A Farrow; Z Ackerman
Journal:  Radiology       Date:  1992-01       Impact factor: 11.105

10.  Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolites.

Authors:  J Frahm; H Bruhn; M L Gyngell; K D Merboldt; W Hänicke; R Sauter
Journal:  Magn Reson Med       Date:  1989-07       Impact factor: 4.668
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  3 in total

Review 1.  Hepatic encephalopathy as a complication of liver disease.

Authors:  S vom Dahl; G Kircheis; D Häussinger
Journal:  World J Gastroenterol       Date:  2001-04       Impact factor: 5.742

2.  Measuring brain uptake and incorporation into brain phosphatidylinositol of plasma myo-[2H6]inositol in unanesthetized rats: an approach to estimate in vivo brain phosphatidylinositol turnover.

Authors:  Kaizong Ma; Joseph Deutsch; Nelly E Villacreses; Thad A Rosenberger; Stanley I Rapoport; H Umesha Shetty
Journal:  Neurochem Res       Date:  2006-06-22       Impact factor: 3.996

3.  Effect of ammonia and methionine sulfoximine on myo-inositol transport in cultured astrocytes.

Authors:  R E Isaacks; A S Bender; C Y Kim; Y F Shi; M D Norenberg
Journal:  Neurochem Res       Date:  1999-01       Impact factor: 3.996
  3 in total

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