Literature DB >> 8216160

CGP 36742: the first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys.

C Mondadori1, J Jaekel, G Preiswerk.   

Abstract

The learning capacity of experimental animals in cognitive tests can be improved by blockade of the GABAB receptors. After treatment with the GABAB antagonist CGP 36742, mice performed better in a passive-avoidance test; rats did likewise in a partner-recognition test, and rhesus monkeys also in a "conditional spatial color" task. The effects demonstrated in these three different species and covering diverse manifestations of learning and memory give reason to hope that this new active principle may prove therapeutically useful.

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Year:  1993        PMID： 8216160     DOI： 10.1016/0163-1047(93)90729-2

Source DB:  PubMed          Journal:  Behav Neural Biol        ISSN： 0163-1047


  22 in total

1.  GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS.

Authors:  U Stäubli; J Scafidi; D Chun
Journal:  J Neurosci       Date:  1999-06-01       Impact factor: 6.167

Review 2.  Is the GABA B heterodimer a good drug target?

Authors:  Fiona H Marshall
Journal:  J Mol Neurosci       Date:  2005       Impact factor: 3.444

3.  Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats.

Authors:  Styliani Vlachou; Neil E Paterson; Sebastien Guery; Klemens Kaupmann; Wolfgang Froestl; Deboshri Banerjee; M G Finn; Athina Markou
Journal:  Eur J Pharmacol       Date:  2011-01-22       Impact factor: 4.432

4.  Regulation of muscarinic acetylcholine receptor-mediated synaptic responses by GABA(B) receptors in the rat hippocampus.

Authors:  R A Morton; N A Manuel; D O Bulters; S R Cobb; C H Davies
Journal:  J Physiol       Date:  2001-09-15       Impact factor: 5.182

5.  Delayed emergence of effects of memory-enhancing drugs: implications for the dynamics of long-term memory.

Authors:  C Mondadori; B Hengerer; T Ducret; J Borkowski
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205

6.  Comparison of antagonist potencies at pre- and post-synaptic GABA(B) receptors at inhibitory synapses in the CA1 region of the rat hippocampus.

Authors:  M F Pozza; N A Manuel; M Steinmann; W Froestl; C H Davies
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

7.  Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory.

Authors:  Miho Terunuma; Raquel Revilla-Sanchez; Isabel M Quadros; Qiudong Deng; Tarek Z Deeb; Michael Lumb; Piotr Sicinski; Philip G Haydon; Menelas N Pangalos; Stephen J Moss
Journal:  J Neurosci       Date:  2014-01-15       Impact factor: 6.167

8.  Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory.

Authors:  Mary Chebib; Tina Hinton; Katrina L Schmid; Darren Brinkworth; Haohua Qian; Susana Matos; Hye-Lim Kim; Heba Abdel-Halim; Rohan J Kumar; Graham A R Johnston; Jane R Hanrahan
Journal:  J Pharmacol Exp Ther       Date:  2008-11-04       Impact factor: 4.030

9.  Specific roles of GABA(B(1)) receptor isoforms in cognition.

Authors:  Laura H Jacobson; Peter H Kelly; Bernhard Bettler; Klemens Kaupmann; John F Cryan
Journal:  Behav Brain Res       Date:  2007-04-05       Impact factor: 3.332

10.  Human brain somatostatin release from isolated cortical nerve endings and its modulation through GABAB receptors.

Authors:  G Bonanno; A Gemignani; G Schmid; P Severi; P Cavazzani; M Raiteri
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739
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