Literature DB >> 8215583

In situ hybridization analysis of cytokine, proto-oncogene and tumour suppressor gene expression in psoriasis.

P Schmid1, D Cox, G K McMaster, P Itin.   

Abstract

The purpose of this study was to investigate and to compare, by in situ hybridization, gene expression of IL-1 beta, IL-8, TGF-beta 1, TGF-beta 2, TGF-beta 3, TGF-alpha, p53 and c-myc in lesions and in non-involved skin of patients with psoriasis. All lesional skin biopsies showed overexpression of IL-1 beta, IL-8 TGF-alpha mRNAs. IL-1 beta hybridization signals were strong in a small number of cells localized predominantly in the dermal papillae and in the suprapapillary epidermis. Overexpression of TGF-alpha was observed in all suprabasal keratinocytes, whereas strongly elevated IL-8 mRNA expression was found to be restricted to clusters of suprabasal keratinocytes. TGF-beta 3, p53 and c-myc transcripts were clearly detected in the epidermis of all biopsies, although expression levels were comparable in lesional and non-lesional skin.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8215583     DOI： 10.1007/bf00371833

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  25 in total

1.  The cytokine network in psoriasis.

Authors:  B J Nickoloff
Journal:  Arch Dermatol       Date:  1991-06

2.  Psoriasis.

Authors:  L Fry
Journal:  Br J Dermatol       Date:  1988-10       Impact factor: 9.302

3.  IL-1 activity is reduced in psoriatic skin. Decreased IL-1 alpha and increased nonfunctional IL-1 beta.

Authors:  K D Cooper; C Hammerberg; O Baadsgaard; J T Elder; L S Chan; D N Sauder; J J Voorhees; G Fisher
Journal:  J Immunol       Date:  1990-06-15       Impact factor: 5.422

4.  Transforming growth factor-beta 1 localization in normal and psoriatic epidermal keratinocytes in situ.

Authors:  C J Kane; A M Knapp; J N Mansbridge; P C Hanawalt
Journal:  J Cell Physiol       Date:  1990-07       Impact factor: 6.384

5.  TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells.

Authors:  Y Choi; E Fuchs
Journal:  Cell Regul       Date:  1990-10

6.  Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis.

Authors:  B J Nickoloff; G D Karabin; J N Barker; C E Griffiths; V Sarma; R S Mitra; J T Elder; S L Kunkel; V M Dixit
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307

7.  Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product.

Authors:  J A Pietenpol; K Münger; P M Howley; R W Stein; H L Moses
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

8.  Neutrophil-activating proteins in psoriasis.

Authors:  J M Schröder; H Gregory; J Young; E Christophers
Journal:  J Invest Dermatol       Date:  1992-02       Impact factor: 8.551

9.  Role of transforming growth factor beta in the maturation of human epidermal keratinocytes.

Authors:  J N Mansbridge; P C Hanawalt
Journal:  J Invest Dermatol       Date:  1988-03       Impact factor: 8.551

10.  Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes.

Authors:  A B Gottlieb; C K Chang; D N Posnett; B Fanelli; J P Tam
Journal:  J Exp Med       Date:  1988-02-01       Impact factor: 14.307
View more
  2 in total

1.  Pathogenic function of IL-1 beta in psoriasiform skin lesions of flaky skin (fsn/fsn) mice.

Authors:  M Schön; C Behmenburg; D Denzer; M P Schön
Journal:  Clin Exp Immunol       Date:  2001-03       Impact factor: 4.330

2.  Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis.

Authors:  M Detmar; L F Brown; K P Claffey; K T Yeo; O Kocher; R W Jackman; B Berse; H F Dvorak
Journal:  J Exp Med       Date:  1994-09-01       Impact factor: 14.307
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.