Literature DB >> 8213692

Toward a comparative overview of dependence potential and acute toxicity of psychoactive substances used nonmedically.

R S Gable1.   

Abstract

A procedure is outlined for comparing dependence potential and acute toxicity across a broad range of abused psychoactive substances. Tentative results, based on an extensive literature review of 20 substances, suggested that the margin of safety ("therapeutic index") varied dramatically between substances. Intravenous heroin appeared to have the greatest risk of dependence and acute lethality; oral psilocybin appeared to have the least. Hazards due to behavioral deficits, perceptual distortion, or chronic illness were not factored into the assessments.

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Year:  1993        PMID： 8213692     DOI： 10.3109/00952999309001618

Source DB:  PubMed          Journal:  Am J Drug Alcohol Abuse        ISSN： 0095-2990            Impact factor:   3.829


  13 in total

Review 1.  Human hallucinogen research: guidelines for safety.

Authors:  Mw Johnson; Wa Richards; Rr Griffiths
Journal:  J Psychopharmacol       Date:  2008-07-01       Impact factor: 4.153

2.  Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse.

Authors:  Shaunna L Clark; Nathan A Gillespie; Daniel E Adkins; Kenneth S Kendler; Michael C Neale
Journal:  Addict Behav       Date:  2015-10-17       Impact factor: 3.913

Review 3.  Lysergic acid diethylamide: a drug of 'use'?

Authors:  Saibal Das; Preeti Barnwal; Anand Ramasamy; Sumalya Sen; Somnath Mondal
Journal:  Ther Adv Psychopharmacol       Date:  2016-03-23

4.  Psilocybin, psychological distress, and suicidality.

Authors:  Peter S Hendricks; Matthew W Johnson; Roland R Griffiths
Journal:  J Psychopharmacol       Date:  2015-09       Impact factor: 4.153

Review 5.  The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act.

Authors:  Matthew W Johnson; Roland R Griffiths; Peter S Hendricks; Jack E Henningfield
Journal:  Neuropharmacology       Date:  2018-06-05       Impact factor: 5.250

6.  Electronic cigarette dependence and demand among pod mod users as a function of smoking status.

Authors:  Eleanor L S Leavens; Tracy T Smith; Noelle Natale; Matthew J Carpenter
Journal:  Psychol Addict Behav       Date:  2020-04-16

7.  Controlling illegal stimulants: a regulated market model.

Authors:  Mark Haden
Journal:  Harm Reduct J       Date:  2008-01-23

8.  Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach.

Authors:  Dirk W Lachenmeier; Jürgen Rehm
Journal:  Sci Rep       Date:  2015-01-30       Impact factor: 4.379

Review 9.  The Therapeutic Potential of Psilocybin.

Authors:  Henry Lowe; Ngeh Toyang; Blair Steele; Henkel Valentine; Justin Grant; Amza Ali; Wilfred Ngwa; Lorenzo Gordon
Journal:  Molecules       Date:  2021-05-15       Impact factor: 4.411

10.  Comparative risk assessment of tobacco smoke constituents using the margin of exposure approach: the neglected contribution of nicotine.

Authors:  Claudia Baumung; Jürgen Rehm; Heike Franke; Dirk W Lachenmeier
Journal:  Sci Rep       Date:  2016-10-19       Impact factor: 4.379
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