| Literature DB >> 8212670 |
L Barbolla1, C Paniagua, J Outeiriño, E Prieto, J Sánchez Fayos.
Abstract
Auto-immune haemolytic anaemia (AIHA) has been found in a case of alpha-interferon treatment. Serum antibody and eluate were positive in the absence of the drug. Although the patient recovered after the treatment was stopped, DAGT remained positive for at least 8 months. The mechanism proposed to explain why this drug induced AIHA is similar to that proposed for alpha-methyl-dopa. Drugs could alter the red cell membrane and impair the immune system. Such changes have been observed with alpha-interferon and were related with increased autoimmunity.Entities:
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Year: 1993 PMID： 8212670 DOI： 10.1111/j.1423-0410.1993.tb02135.x
Source DB: PubMed Journal: Vox Sang ISSN： 0042-9007 Impact factor: 2.144