Literature DB >> 8212553

Clonal expansion of hypermutated measles virus in a SSPE brain.

K Baczko1, J Lampe, U G Liebert, U Brinckmann, V ter Meulen, I Pardowitz, H Budka, S L Cosby, S Isserte, B K Rima.   

Abstract

Nucleotide sequence analysis was carried out to study genes encoding the matrix (M) protein of measles virus (MV) from several regions of the brain of a case of subacute sclerosing panencephalitis. This analysis revealed the presence of MV with "wild-type" sequences as well as variants which had undergone at least five biased hypermutation events (U to C and A to G in the positive strand sequences). Despite the presence of MV variants with genes encoding the intact matrix protein open reading frame, M protein could not be detected in any of the brain regions. The distribution of virus variants was studied by cDNA cloning and sequence analysis and by in situ hybridization. The hypermutated viruses appeared to expand clonally throughout the brain of patient B.

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Year:  1993        PMID： 8212553     DOI： 10.1006/viro.1993.1579

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  34 in total

1.  Polyploid measles virus with hexameric genome length.

Authors:  Monika Rager; Sompong Vongpunsawad; William Paul Duprex; Roberto Cattaneo
Journal:  EMBO J       Date:  2002-05-15       Impact factor: 11.598

2.  Generation of coronavirus spike deletion variants by high-frequency recombination at regions of predicted RNA secondary structure.

Authors:  C L Rowe; J O Fleming; M J Nathan; J Y Sgro; A C Palmenberg; S C Baker
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

3.  RNA interference with measles virus N, P, and L mRNAs efficiently prevents and with matrix protein mRNA enhances viral transcription.

Authors:  Thorsten Reuter; Benedikt Weissbrich; Sibylle Schneider-Schaulies; Jürgen Schneider-Schaulies
Journal:  J Virol       Date:  2006-06       Impact factor: 5.103

Review 4.  Measles virus, immune control, and persistence.

Authors:  Diane E Griffin; Wen-Hsuan Lin; Chien-Hsiung Pan
Journal:  FEMS Microbiol Rev       Date:  2012-03-13       Impact factor: 16.408

Review 5.  Enhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinase.

Authors:  Jean-François Gélinas; Guerline Clerzius; Eileen Shaw; Anne Gatignol
Journal:  J Virol       Date:  2011-04-13       Impact factor: 5.103

6.  Weak cis and trans Interactions of the Hemagglutinin with Receptors Trigger Fusion Proteins of Neuropathogenic Measles Virus Isolates.

Authors:  Yuta Shirogane; Takao Hashiguchi; Yusuke Yanagi
Journal:  J Virol       Date:  2020-01-06       Impact factor: 5.103

Review 7.  Subacute sclerosing panencephalitis.

Authors:  R K Garg
Journal:  Postgrad Med J       Date:  2002-02       Impact factor: 2.401

Review 8.  Case report and molecular analysis of subacute sclerosing panencephalitis in a South African Child.

Authors:  E Vardas; P M Leary; J Yeats; W Badrodien; S Kreis
Journal:  J Clin Microbiol       Date:  1999-03       Impact factor: 5.948

Review 9.  ADARs: viruses and innate immunity.

Authors:  Charles E Samuel
Journal:  Curr Top Microbiol Immunol       Date:  2012       Impact factor: 4.291

10.  Interleukin (IL)-12, IL-2, interferon-gamma gene polymorphisms in subacute sclerosing panencephalitis patients.

Authors:  Vuslat Yilmaz; Veysi Demirbilek; Candan Gürses; Sibel P Yentür; Serap Uysal; Zuhal Yapici; Gülden Yilmaz; Aaron Muncey; Ozlem Cokar; Emel Onal; Aysen Gökyiğit; Güher Saruhan-Direskeneli
Journal:  J Neurovirol       Date:  2007-10       Impact factor: 2.643
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