Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Peptide T, a novel bradykinin potentiator isolated from Tityus serrulatus scorpion venom.

Literature DB >> 8212046

Peptide T, a novel bradykinin potentiator isolated from Tityus serrulatus scorpion venom.

L A Ferreira¹, E W Alves, O B Henriques.

Abstract

A bradykinin-potentiating peptide was isolated and characterized from venom of the scorpion Tityus serrulatus by chromatographic techniques followed by biological assays. The complete amino acid sequence (13 residues) of peptide is presented. The peptide potentiated the contractile activity of bradykinin on the isolated guinea-pig ileum, and inhibited the hydrolysis of bradykinin by angiotensin-converting enzyme from B. jararaca plasma and the conversion of angiotensin I to angiotensin II by kininase II from guinea-pig ileum tissue. The peptide also increased the depressor effect of bradykinin on arterial blood pressure in the anaesthetized rat.

Entities: Species

Mesh：

Substances：
Scorpion Venoms
Peptide T

Year: 1993 PMID： 8212046 DOI： 10.1016/0041-0101(93)90253-f

Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033

Keyword Cloud
Cited

11 in total

1. Revealing the Function and the Structural Model of Ts4: Insights into the "Non-Toxic" Toxin from Tityus serrulatus Venom.

Authors: Manuela B Pucca; Felipe A Cerni; Steve Peigneur; Karla C F Bordon; Jan Tytgat; Eliane C Arantes
Journal: Toxins (Basel) Date: 2015-07-06 Impact factor: 4.546

2. Transcriptome analysis of scorpion species belonging to the Vaejovis genus.

Authors: Verónica Quintero-Hernández; Santos Ramírez-Carreto; María Teresa Romero-Gutiérrez; Laura L Valdez-Velázquez; Baltazar Becerril; Lourival D Possani; Ernesto Ortiz
Journal: PLoS One Date: 2015-02-06 Impact factor: 3.240

3. Inhibition of Tityus serrulatus venom hyaluronidase affects venom biodistribution.

Authors: Bárbara Bruna Ribeiro de Oliveira-Mendes; Sued Eustáquio Mendes Miranda; Douglas Ferreira Sales-Medina; Bárbara de Freitas Magalhães; Yan Kalapothakis; Renan Pedra de Souza; Valbert Nascimento Cardoso; André Luís Branco de Barros; Clara Guerra-Duarte; Evanguedes Kalapothakis; Carolina Campolina Rebello Horta
Journal: PLoS Negl Trop Dis Date: 2019-04-19

10. Electrophysiological characterization of Ts6 and Ts7, K⁺ channel toxins isolated through an improved Tityus serrulatus venom purification procedure.

Authors: Felipe A Cerni; Manuela B Pucca; Steve Peigneur; Caroline M Cremonez; Karla C F Bordon; Jan Tytgat; Eliane C Arantes
Journal: Toxins (Basel) Date: 2014-02-28 Impact factor: 4.546

Peptide T, a novel bradykinin potentiator isolated from Tityus serrulatus scorpion venom.

1. Revealing the Function and the Structural Model of Ts4: Insights into the "Non-Toxic" Toxin from Tityus serrulatus Venom.

2. Transcriptome analysis of scorpion species belonging to the Vaejovis genus.

3. Inhibition of Tityus serrulatus venom hyaluronidase affects venom biodistribution.

Review 4. Serotherapy against Voltage-Gated Sodium Channel-Targeting αToxins from Androctonus Scorpion Venom.

5. Hypothesized and found mechanisms for potentiation of bradykinin actions.

Review 6. Scorpion venom components as potential candidates for drug development.

7. Potentiation of bradykinin actions by analogues of the bradykinin potentiating nonapeptide BPP9alpha.

8. Evaluation of the in vivo antihypertensive effect and antioxidant activity of HL-7 and HL-10 peptide in mice.

9. Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones).

10. Electrophysiological characterization of Ts6 and Ts7, K⁺ channel toxins isolated through an improved Tityus serrulatus venom purification procedure.