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Literature DB >> 821146

Complete covalent structure of a human IgA1 immunoglobulin.

Y S Liu, T L Low, A Infante, F W Putnam.

Abstract

The complete covalent structure has been determined for a human myeloma IgA1 immunoglobulin. This protein has unique features in the amino acid sequence and disulfide bridge structure of the variable (V) and constant (C) regions of both the alpha heavy and the lambda light chains, and in the number and loci of oligosaccharides. Whereas C region domains of heavy chains have evolved independently over eons, recent isotypic variations have occured in lambda light chains and possibly in alpha heavy chains.

Entities: Chemical Disease Gene Species

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Year: 1976 PMID： 821146 DOI： 10.1126/science.821146

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

29 in total

1. Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study.

Authors: Michelle M Gomes; Hitoshi Suzuki; Monica T Brooks; Milan Tomana; Zina Moldoveanu; Jiri Mestecky; Bruce A Julian; Jan Novak; Andrew B Herr
Journal: Biochemistry Date: 2010-07-13 Impact factor: 3.162

2. Identification of non-immunoglobulin A-Fc-binding forms and low-molecular-weight secreted forms of the group B streptococcal beta antigen.

Authors: L J Brady; M D Boyle
Journal: Infect Immun Date: 1989-05 Impact factor: 3.441

10. Analysis of the specificity of bacterial immunoglobulin A (IgA) proteases by a comparative study of ape serum IgAs as substrates.

Authors: J Qiu; G P Brackee; A G Plaut
Journal: Infect Immun Date: 1996-03 Impact factor: 3.441

Complete covalent structure of a human IgA1 immunoglobulin.

1. Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study.

2. Identification of non-immunoglobulin A-Fc-binding forms and low-molecular-weight secreted forms of the group B streptococcal beta antigen.

Review 3. Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families.

4. Possible palindromes in immunoglobulin heavy-chain genes: Their role in membrane attachment.

5. Evolution of the IgA heavy chain gene in the genus Mus.

6. Structure of the A2m(1) allotype of human IgA--a recombinant molecule.

7. Evidence for a site-specific fucosylation of N-linked oligosaccharide of immunoglobulin A1 from normal human serum.

8. The thiol groups of mouse immunoglobulin A. Incomplete formation of the C alpha 1-domain disulphide bridge.

9. Human immunoglobulin heavy chain A2 gene allotype determination by restriction fragment length polymorphism.

10. Analysis of the specificity of bacterial immunoglobulin A (IgA) proteases by a comparative study of ape serum IgAs as substrates.