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Literature DB >> 821118

The fate of ME7 scrapie infection in rats, guinea-pigs and rabbits.

Abstract

The fate of an intracerebral injection of ME7 scrapie has been followed in groups of rats, guinea-pigs and rabbits. Six days after injection scrapie activity in the brain was similar in all three species and low levels of activity were also present in rat and guinea-pig spleen. Thereafter in the rat the pattern of accumulation of scrapie agent in brain and spleen resembled that frequently described in mice, the disease becoming clinically manifest 20 months after injection. In guinea-pig and rabbit attempts to demonstrate scrapie agent at later stages of lifespan were generally unsuccessful. It is tentatively concluded that in these last two species replication of scrapie agent did not occur though in the guinea-pig there was some evidence that infection could persist for several months. An alternative explanation of the results is briefly discussed.

Entities: Disease Species

Mesh：

Substances：
Prions

Year: 1976 PMID： 821118

Source DB: PubMed Journal: Res Vet Sci ISSN： 0034-5288 Impact factor: 2.534

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Cited

24 in total

1. The intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions: a replica exchange molecular dynamics study.

Authors: Xiaoliang Lu; Juan Zeng; Ya Gao; John Z H Zhang; Dawei Zhang; Ye Mei
Journal: J Mol Model Date: 2013-09-17 Impact factor: 1.810

2. Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP.

Authors: M Qasim Khan; Braden Sweeting; Vikram Khipple Mulligan; Pharhad Eli Arslan; Neil R Cashman; Emil F Pai; Avijit Chakrabartty
Journal: Proc Natl Acad Sci U S A Date: 2010-11-01 Impact factor: 11.205

10. Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism.

Authors: Leonardo M Cortez; Jitendra Kumar; Ludovic Renault; Howard S Young; Valerie L Sim
Journal: J Biol Chem Date: 2013-01-02 Impact factor: 5.157

The fate of ME7 scrapie infection in rats, guinea-pigs and rabbits.

1. The intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions: a replica exchange molecular dynamics study.

2. Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP.

Review 3. In vitro studies of the transmission barrier.

4. Fibril formation of the rabbit/human/bovine prion proteins.

5. Pulling rabbits to reveal the secrets of the prion protein.

Review 6. Progress on low susceptibility mechanisms of transmissible spongiform encephalopathies.

7. Behind the potential evolution towards prion resistant species.

8. Sequence-dependent prion protein misfolding and neurotoxicity.

9. Expression and distribution of laminin receptor precursor/laminin receptor in rabbit tissues.

10. Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism.