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Literature DB >> 8211113

Correspondence between a mammalian spliceosome component and an essential yeast splicing factor.

Abstract

None of the mammalian splicing factors that have been cloned corresponds to the yeast pre-messenger RNA splicing factors, the PRP proteins. Here, a generalizable strategy was used to isolate a complementary DNA encoding the mammalian spliceosome-associated protein (SAP) SAP 62. It is demonstrated that SAP 62 is the likely functional homolog of the yeast PRP11 protein. Both PRP11 and SAP 62 associate stably with the spliceosome, contain a single zinc finger, and display significant amino acid sequence similarity. Unlike PRP11, SAP 62 contains 22 proline-rich heptapeptide repeats at the carboxyl-terminus.

Entities: Chemical Gene Species

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Year: 1993 PMID： 8211113 DOI： 10.1126/science.8211113

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

40 in total

1. Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction.

Authors: G Ast; T Pavelitz; A M Weiner
Journal: Nucleic Acids Res Date: 2001-04-15 Impact factor: 16.971

2. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

Authors: P Ajuh; B Kuster; K Panov; J C Zomerdijk; M Mann; A I Lamond
Journal: EMBO J Date: 2000-12-01 Impact factor: 11.598

3. Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation.

Authors: D Nesic; A Krämer
Journal: Mol Cell Biol Date: 2001-10 Impact factor: 4.272

4. Mutation in the prp12+ gene encoding a homolog of SAP130/SF3b130 causes differential inhibition of pre-mRNA splicing and arrest of cell-cycle progression in Schizosaccharomyces pombe.

Authors: Y Habara; S Urushiyama; T Shibuya; Y Ohshima; T Tani
Journal: RNA Date: 2001-05 Impact factor: 4.942

10. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif.

Authors: M T Bedford; R Reed; P Leder
Journal: Proc Natl Acad Sci U S A Date: 1998-09-01 Impact factor: 11.205

Correspondence between a mammalian spliceosome component and an essential yeast splicing factor.

1. Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction.

2. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

3. Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation.

4. Mutation in the prp12+ gene encoding a homolog of SAP130/SF3b130 causes differential inhibition of pre-mRNA splicing and arrest of cell-cycle progression in Schizosaccharomyces pombe.

5. Structure and assembly of the SF3a splicing factor complex of U2 snRNP.

6. Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43.

7. The yeast U2A'/U2B complex is required for pre-spliceosome formation.

8. A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site.

9. CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif.

10. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif.