Literature DB >> 8208407

Electron transport chain defects in Alzheimer's disease brain.

W D Parker1, J Parks, C M Filley, B K Kleinschmidt-DeMasters.   

Abstract

Previous work suggested a deficiency in the terminal complex of the mitochondrial electron transport chain, cytochrome c oxidase (COX), in platelet mitochondria of Alzheimer's disease (AD) patients. The present study extends this observation to AD brain mitochondria through assay of electron transport chain activities in mitochondria isolated from autopsied brain samples from AD patients (n = 9) and from controls with and without known neurologic disease (n = 8). AD brain mitochondria demonstrated a generalized depression of activity of all electron transport chain complexes. This depression was most marked in COX activity (p < 0.001). Concentrations of cytochromes b, c1, and aa3 were similar in AD and controls. The electron transport chain is defective in AD brain, and the defect centers about COX.

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Year:  1994        PMID： 8208407     DOI： 10.1212/wnl.44.6.1090

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  128 in total

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8.  Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD mice.

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Review 9.  Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer's Disease.

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Review 10.  Oxidative stress signaling in Alzheimer's disease.

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