Literature DB >> 8208406

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease.

W D Parker1, N J Mahr, C M Filley, J K Parks, D Hughes, D A Young, C M Cullum.   

Abstract

We evaluated a simplified method for preparation and analysis of platelet cytochrome c oxidase activity in Alzheimer's disease (AD) and control patients. Mean cytochrome c oxidase activity in controls (n = 17) was 0.233 sec-1/mg whereas mean cytochrome c oxidase activity in Alzheimer patients (n = 19) was 0.193 sec-1/mg, p = 0.033. Complex III (ubiquinol:cytochrome c oxidoreductase), complex II (succinic dehydrogenase), and citrate synthase were all assayed as internal controls and were not significantly different in controls and Alzheimer patients. There is a relatively specific loss of platelet cytochrome c oxidase activity in Alzheimer disease patients.

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Year:  1994        PMID： 8208406     DOI： 10.1212/wnl.44.6.1086

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  59 in total

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