| Literature DB >> 8207958 |
C A Schmidt1, H Oettle, W D Ludwig, S Serke, B Pawlaczyk-Peter, F Wilborn, L T Binder, D Huhn, W Siegert.
Abstract
The Raf-1 protein, a cytoplasmic serine/threonine kinase, plays an important role in signal transduction pathways. In order to examine the role of Raf-1 in human myeloid leukemia, we determined raf-1 mRNA expression by Northern blot analysis in blast cell samples from 27 acute myeloid leukemia (AML) cases and peripheral blood mononuclear cells from six healthy donors. A normal raf-1 transcript size was detected in all cases investigated. However, overexpression of raf-1 mRNA was found in 2 of 27 AML cases, both of which were erythroleukemias (AML, FAB M6).Entities:
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Year: 1994 PMID： 8207958 DOI： 10.1016/0145-2126(94)90076-0
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156