Literature DB >> 8206955

DNA bending by Saccharomyces cerevisiae ABF1 and its proteolytic fragments.

L D McBroom1, P D Sadowski.   

Abstract

The ABF1 protein of the yeast Saccharomyces cerevisiae has been found to bend the DNA containing the target site for DNA binding. A bend angle of about 120 degrees was measured and the bend center was 7 base pairs to the 5' end of the ABF1 consensus-containing sequence. Phasing analysis showed that intact ABF1 bends the DNA towards the minor groove. We have subjected ABF1 to partial proteolysis and have found that proteolytic fragments were able to bind to the DNA-binding site and induce partial bends in the DNA. Interestingly, the locations of the bend centers, the bend angles, and the plane of the bends induced by the proteolytic peptides of ABF1 were different from those of the intact protein. We present a model for the mechanism of bending of DNA by ABF1.

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Year:  1994        PMID： 8206955

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  13 in total

1.  Transcriptional regulation of the SMK1 mitogen-activated protein kinase gene during meiotic development in Saccharomyces cerevisiae.

Authors:  M Pierce; M Wagner; J Xie; V Gailus-Durner; J Six; A K Vershon; E Winter
Journal:  Mol Cell Biol       Date:  1998-10       Impact factor: 4.272

2.  Regulation of gene expression during meiosis in Saccharomyces cerevisiae: SPR3 is controlled by both ABFI and a new sporulation control element.

Authors:  N Ozsarac; M J Straffon; H E Dalton; I W Dawes
Journal:  Mol Cell Biol       Date:  1997-03       Impact factor: 4.272

3.  Similar upstream regulatory elements of genes that encode the two largest subunits of RNA polymerase II in Saccharomyces cerevisiae.

Authors:  D B Jansma; J Archambault; O Mostachfi; J D Friesen
Journal:  Nucleic Acids Res       Date:  1996-11-15       Impact factor: 16.971

4.  Different roles for abf1p and a T-rich promoter element in nucleosome organization of the yeast RPS28A gene.

Authors:  R F Lascaris; E Groot; P B Hoen; W H Mager; R J Planta
Journal:  Nucleic Acids Res       Date:  2000-03-15       Impact factor: 16.971

5.  The nonconserved hinge region and distinct amino-terminal domains of the ROR alpha orphan nuclear receptor isoforms are required for proper DNA bending and ROR alpha-DNA interactions.

Authors:  L D McBroom; G Flock; V Giguère
Journal:  Mol Cell Biol       Date:  1995-02       Impact factor: 4.272

6.  Interactions of the yeast centromere and promoter factor, Cpf1p, with the cytochrome c1 upstream region and functional implications on regulated gene expression.

Authors:  U Oechsner; W Bandlow
Journal:  Nucleic Acids Res       Date:  1996-06-15       Impact factor: 16.971

7.  Participation of the yeast activator Abf1 in meiosis-specific expression of the HOP1 gene.

Authors:  V Gailus-Durner; J Xie; C Chintamaneni; A K Vershon
Journal:  Mol Cell Biol       Date:  1996-06       Impact factor: 4.272

8.  Analysis of chromosome III replicators reveals an unusual structure for the ARS318 silencer origin and a conserved WTW sequence within the origin recognition complex binding site.

Authors:  Fujung Chang; James F Theis; Jeremy Miller; Conrad A Nieduszynski; Carol S Newlon; Michael Weinreich
Journal:  Mol Cell Biol       Date:  2008-06-23       Impact factor: 4.272

9.  The upstream region of the FOX3 gene encoding peroxisomal 3-oxoacyl-coenzyme A thiolase in Saccharomyces cerevisiae contains ABF1- and replication protein A-binding sites that participate in its regulation by glucose repression.

Authors:  A W Einerhand; W Kos; W C Smart; A J Kal; H F Tabak; T G Cooper
Journal:  Mol Cell Biol       Date:  1995-06       Impact factor: 4.272

Review 10.  Control of glycolytic gene expression in the budding yeast (Saccharomyces cerevisiae).

Authors:  A Chambers; E A Packham; I R Graham
Journal:  Curr Genet       Date:  1995-12       Impact factor: 3.886
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