Literature DB >> 8206887

A hydrophilic tetrahydro-beta-carboline in human urine.

K Horiuchi1, O Yonekawa, K Iwahara, T Kanno, T Kurihara, Y Fujise.   

Abstract

A substance that exhibited a tryptophan-like fluorescence peak at 354 nm on excitation at 295 nm at neutral pH was isolated from human urine. This compound was determined by visible-light absorption spectroscopy, fluorescence spectroscopy, 1H and 13C NMR spectroscopies, and FAB-MS to be 1-(1',2',3',4',5'-pentahydroxypentyl)-1,2,3,4-tetrahydro-2-carboli ne-3- carboxylic acid. This compound, named tetrahydropentoxyline, is a new type of hydrophilic tetrahydro-beta-carboline, and its elution position was between those of 4-pyridoxic acid and kynurenic acid on C18 reversed-phase HPLC. The amount of tetrahydropentoxyline excreted in the urine of normal subjects [n = 21; age, 45 (SD 20) years] was about 5.2 (SD 1.0) mg per day.

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Year:  1994        PMID： 8206887     DOI： 10.1093/oxfordjournals.jbchem.a124343

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  9 in total

1.  Tryptophan glycoconjugates in food and human urine.

Authors:  B Gutsche; C Grun; D Scheutzow; M Herderich
Journal:  Biochem J       Date:  1999-10-01       Impact factor: 3.857

2.  Enrichment and characterization of a bacterial mixture capable of utilizing C-mannosyl tryptophan as a carbon source.

Authors:  Tanim J Hossain; Shino Manabe; Yukishige Ito; Toshiya Iida; Saori Kosono; Kenji Ueda; Akira Hosomi; Daishi Inoue; Tadashi Suzuki
Journal:  Glycoconj J       Date:  2018-01-15       Impact factor: 2.916

3.  A novel assay for detection and quantification of C-mannosyl tryptophan in normal or diabetic mice.

Authors:  Sho Sakurai; Yoko Inai; Shiho Minakata; Shino Manabe; Yukishige Ito; Yoshito Ihara
Journal:  Sci Rep       Date:  2019-03-18       Impact factor: 4.379

4.  Systematic Isolation and Structure Elucidation of Urinary Metabolites Optimized for the Analytical-Scale Molecular Profiling Laboratory.

Authors:  Luke Whiley; Elena Chekmeneva; David J Berry; Beatriz Jiménez; Ada H Y Yuen; Ash Salam; Humma Hussain; Matthias Witt; Zoltan Takats; Jeremy Nicholson; Matthew R Lewis
Journal:  Anal Chem       Date:  2019-07-01       Impact factor: 6.986

5.  Quantification of serum C-mannosyl tryptophan by novel assay to evaluate renal function and vascular complications in patients with type 2 diabetes.

Authors:  Shuhei Morita; Yoko Inai; Shiho Minakata; Shohei Kishimoto; Shino Manabe; Naoyuki Iwahashi; Kazuhiko Ino; Yukishige Ito; Takashi Akamizu; Yoshito Ihara
Journal:  Sci Rep       Date:  2021-01-21       Impact factor: 4.379

6.  Formation, Characterization, and Occurrence of β-Carboline Alkaloids Derived from α-Dicarbonyl Compounds and l-Tryptophan.

Authors:  Tomás Herraiz; Adriana Peña; Haroll Mateo; Marta Herraiz; Antonio Salgado
Journal:  J Agric Food Chem       Date:  2022-07-12       Impact factor: 5.895

7.  Is Fluorescence Valid to Monitor Removal of Protein Bound Uremic Solutes in Dialysis?

Authors:  Jürgen Arund; Merike Luman; Fredrik Uhlin; Risto Tanner; Ivo Fridolin
Journal:  PLoS One       Date:  2016-05-26       Impact factor: 3.240

8.  C-Mannosyl tryptophan increases in the plasma of patients with ovarian cancer.

Authors:  Naoyuki Iwahashi; Yoko Inai; Shiho Minakata; Sho Sakurai; Shino Manabe; Yukishige Ito; Kazuhiko Ino; Yoshito Ihara
Journal:  Oncol Lett       Date:  2019-11-28       Impact factor: 2.967

Review 9.  Protein C-Mannosylation and C-Mannosyl Tryptophan in Chemical Biology and Medicine.

Authors:  Shiho Minakata; Shino Manabe; Yoko Inai; Midori Ikezaki; Kazuchika Nishitsuji; Yukishige Ito; Yoshito Ihara
Journal:  Molecules       Date:  2021-08-30       Impact factor: 4.411
  9 in total

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