Literature DB >> 8205358

Expression of insulin-like growth factor II by a gastric carcinoma associated with hypoglycaemia.

T Horiuchi1, Y Shinohara, Y Sakamoto, N Hizuka, T Watabe, O Mokuda, K Tanaka, N Shimizu, I Sugano, K Nagao.   

Abstract

A gastric cancer with liver metastases was associated with low morning levels of plasma glucose (24 mg/dl), insulin (< 2.5 microU/ml) and growth hormone (0.23 ng/ml). Primary and metastatic tumour tissue stained positively with anti-insulin-like growth factor II (IGF-II) monoclonal antibody. Western immunoblot analysis revealed a high molecular weight IGF-II in the serum: 15 kDa (normal: 7.5 kDa). Postmortem reverse transcription polymerase chain reaction on mRNA from both sites revealed 471 base pairs size cDNA encoding prepro-IGF-II. These results suggest that the gastric carcinoma encoded, expressed, and secreted IGF-II, probably causing the extrapancreatic tumour hypoglycaemia.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8205358     DOI： 10.1007/bf00190569

Source DB:  PubMed          Journal:  Virchows Arch        ISSN： 0945-6317            Impact factor:   4.064


  17 in total

1.  Radioimmunoassay for insulin-like growth factor II (IGF-II).

Authors:  K Asakawa; N Hizuka; K Takano; I Fukuda; I Sukegawa; H Demura; K Shizume
Journal:  Endocrinol Jpn       Date:  1990-10

2.  Hypoglycemia in association with extrapancreatic tumors: demonstration of elevated plasma NSILA-s by a new radioreceptor assay.

Authors:  K Megyesi; C R Kahn; J Roth; P Gorden
Journal:  J Clin Endocrinol Metab       Date:  1974-05       Impact factor: 5.958

3.  Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

Authors:  G K Haselbacher; J C Irminger; J Zapf; W H Ziegler; R E Humbel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

4.  Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia.

Authors:  J Zapf; C Schmid; H P Guler; M Waldvogel; C Hauri; E Futo; P Hossenlopp; M Binoux; E R Froesch
Journal:  J Clin Invest       Date:  1990-09       Impact factor: 14.808

5.  Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene.

Authors:  A Gray; A W Tam; T J Dull; J Hayflick; J Pintar; W K Cavenee; A Koufos; A Ullrich
Journal:  DNA       Date:  1987-08

6.  Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia.

Authors:  W H Daughaday; M A Emanuele; M H Brooks; A L Barbato; M Kapadia; P Rotwein
Journal:  N Engl J Med       Date:  1988-12-01       Impact factor: 91.245

7.  Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?

Authors:  J Zapf; E Futo; M Peter; E R Froesch
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

8.  Is extrapancreatic tumor hypoglycemia associated with elevated levels of insulin-like growth factor II?

Authors:  U Widmer; J Zapf; E R Froesch
Journal:  J Clin Endocrinol Metab       Date:  1982-11       Impact factor: 5.958

9.  Measurement of insulin-like growth factor II by a specific radioreceptor assay in serum of normal individuals, patients with abnormal growth hormone secretion, and patients with tumor-associated hypoglycemia.

Authors:  W H Daughaday; B Trivedi; M Kapadia
Journal:  J Clin Endocrinol Metab       Date:  1981-08       Impact factor: 5.958

10.  Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia.

Authors:  J Zapf; H Walter; E R Froesch
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808
View more
  1 in total

1.  Severe hypoglycemia associated with insulin-like growth factor II-producing liver metastasis from gastric carcinoma treated with overnight total parenteral nutrition via a central vein catheter reserve port.

Authors:  Yohei Koizumi; Atsushi Hiraoka; Kojiro Michitaka; Nayu Tazuya; Misa Ichiryu; Hiromasa Nakahara; Hironori Ochi; Atsushi Tanabe; Satoshi Hidaka; Akihiro Kodama; Takahide Uehara; Aki Hasebe; Yasunao Miyamoto; Tomoyuki Ninomiya; Teru Kumagi; Masanori Abe; Bunzo Matsuura; Norio Horiike; Yoichi Hiasa; Morikazu Onji
Journal:  Clin J Gastroenterol       Date:  2011-01-21
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.