Literature DB >> 8205123

Protective effects of hydroxychalcones on free radical-induced cell damage.

S Sogawa1, Y Nihro, H Ueda, T Miki, H Matsumoto, T Satoh.   

Abstract

A number of hydroxychalcones were synthesized to evaluate their protective effects against oxidative cell damage and the production of superoxide anion. The hydroxychalcones which have a 3,4-dihydroxycinnamoyl structure were potent inhibitors of lipid peroxidation in rat liver microsomes. In particular, we found that 2',4',3,4-tetrahydroxychalcone (3) exhibited a potent inhibitory effect on H2O2-induced hemolysis due to an antioxidant effect. In addition, this compound strongly inhibited CCl4-induced cytotoxicity in primary cultured hepatocytes and substantially decreased the production of superoxide anion by rat peritoneal exudate macrophages.

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Year:  1994        PMID： 8205123     DOI： 10.1248/bpb.17.251

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  11 in total

1.  The Protective Roles of Butein on Indomethacin Induced Gastric Ulcer in Mice.

Authors:  Rustem Anil Ugan; Harun Un
Journal:  Eurasian J Med       Date:  2020-10

2.  3-[4-(Dimethyl-amino)phen-yl]-1-(2-pyrrol-yl)prop-2-en-1-one.

Authors:  Si-Ping Tang; Dai-Zhi Kuang; Yong-Lan Feng; Wei Li; Zhi-Min Chen
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-05-21

3.  3-(4-Methoxy-phen-yl)-1-(2-pyrrol-yl)prop-2-en-1-one.

Authors:  Dong-Qing Li
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-09-13

4.  Butein provides neuroprotective and anti-neuroinflammatory effects through Nrf2/ARE-dependent haem oxygenase 1 expression by activating the PI3K/Akt pathway.

Authors:  Dong-Sung Lee; Gil-Saeng Jeong
Journal:  Br J Pharmacol       Date:  2016-08-31       Impact factor: 8.739

5.  Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress.

Authors:  Agnieszka Szuster-Ciesielska; Magdalena Mizerska-Dudka; Jadwiga Daniluk; Martyna Kandefer-Szerszeń
Journal:  J Gastroenterol       Date:  2012-06-22       Impact factor: 7.527

6.  Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia.

Authors:  Mattia Mori; Luca Tottone; Deborah Quaglio; Nadezda Zhdanovskaya; Cinzia Ingallina; Marisa Fusto; Francesca Ghirga; Giovanna Peruzzi; Maria Elisa Crestoni; Fabrizio Simeoni; Francesca Giulimondi; Claudio Talora; Bruno Botta; Isabella Screpanti; Rocco Palermo
Journal:  Sci Rep       Date:  2017-05-19       Impact factor: 4.379

Review 7.  Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

Authors:  Subhash Padhye; Aamir Ahmad; Nikhil Oswal; Fazlul H Sarkar
Journal:  J Hematol Oncol       Date:  2009-09-02       Impact factor: 17.388

8.  Antimicrobial and antioxidative activities of bioactive constituents from Hydnophytum formicarum Jack.

Authors:  Supaluk Prachayasittikul; Prasit Buraparuangsang; Apilak Worachartcheewan; Chartchalerm Isarankura-Na-Ayudhya; Somsak Ruchirawat; Virapong Prachayasittikul
Journal:  Molecules       Date:  2008-04-18       Impact factor: 4.411

9.  Investigation of antioxidant vitamins (A, E, C) and lipid peroxidation levels in rats injected N-(1,3-benzothiazol-2-yl)-N-(4,5-dihydro-1H-imidazol-2-yl) amine.

Authors:  F Karatas; H Kara; S Servi; T Tug; F A Erulas; M Koca
Journal:  Molecules       Date:  2005-08-31       Impact factor: 4.411

10.  Butein Inhibits Oxidative Stress Injury in Rats with Chronic Heart Failure via ERK/Nrf2 Signaling.

Authors:  Peng Liu; Quanli Pan
Journal:  Cardiovasc Ther       Date:  2022-01-04       Impact factor: 3.023
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