| Literature DB >> 8204661 |
M V Novotny1, M F Yancey, R Stuart, D Wiesler, R G Peterson.
Abstract
Endogenous saturated and unsaturated aldehydes were found in significant elevations in serum of diabetic humans and rats. These compounds, originating from the lipid peroxidation processes, are shown here to be potent inhibitors of the glycolytic enzymes, phosphofructokinase and glyceraldehyde-3-phosphate dehydrogenase. The inhibition process is non-competitive and progressive. The aldehyde mixture, when supplemented to the standard rat diet at 1/100 ratio, caused nerve damage that is reminiscent of diabetic polyneuropathies.Entities:
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Year: 1994 PMID： 8204661 DOI： 10.1016/0925-4439(94)90022-1
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002