Literature DB >> 8204565

Age-related changes in peripheral benzodiazepine receptors of human platelets.

D Marazziti1, M L Pancioli-Guadagnucci, A Rotondo, G Giannaccini, C Martini, A Lucacchini, G B Cassano.   

Abstract

Using 3H-PK 11195 as radioligand, the number and affinity of peripheral benzodiazepine receptors in platelets of 15 elderly healthy subjects were compared to those of 15 young subjects. The results showed that the dissociation constant (Kd) was significantly higher in the elderly than in the young subjects, while the density of binding sites did not differ. These findings suggest that the age-related changes in peripheral benzodiazepine receptors may be coupled with secondary changes in their hypothesized functions.

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Year:  1994        PMID： 8204565      PMCID： PMC1188577     

Source DB:  PubMed          Journal:  J Psychiatry Neurosci        ISSN： 1180-4882            Impact factor:   6.186


  17 in total

1.  Decreased peripheral benzodiazepine binding sites in platelets of neuroleptic-treated schizophrenics.

Authors:  M Gavish; A Weizman; L Karp; S Tyano; Z Tanne
Journal:  Eur J Pharmacol       Date:  1986-02-18       Impact factor: 4.432

2.  Characterization of peripheral-type benzodiazepine binding sites in brain using [3H]Ro 5-4864.

Authors:  P J Marangos; J Patel; J P Boulenger; R Clark-Rosenberg
Journal:  Mol Pharmacol       Date:  1982-07       Impact factor: 4.436

3.  Peripheral-type benzodiazepine receptors in the central nervous system: localization to olfactory nerves.

Authors:  R R Anholt; K M Murphy; G E Mack; S H Snyder
Journal:  J Neurosci       Date:  1984-02       Impact factor: 6.167

Review 4.  Is cell aging caused by respiration-dependent injury to the mitochondrial genome?

Authors:  J E Fleming; J Miquel; S F Cottrell; L S Yengoyan; A C Economos
Journal:  Gerontology       Date:  1982       Impact factor: 5.140

5.  A simplification of the protein assay method of Lowry et al. which is more generally applicable.

Authors:  G L Peterson
Journal:  Anal Biochem       Date:  1977-12       Impact factor: 3.365

6.  Neurosteroids: steroidogenesis in primary cultures of rat glial cells after release of aminoglutethimide blockade.

Authors:  Z Y Hu; I Jung-Testas; P Robel; E E Baulieu
Journal:  Biochem Biophys Res Commun       Date:  1989-06-15       Impact factor: 3.575

7.  Solubilization and reassembly of the mitochondrial benzodiazepine receptor.

Authors:  R R Anholt; U Aebi; P L Pedersen; S H Snyder
Journal:  Biochemistry       Date:  1986-04-22       Impact factor: 3.162

8.  Age-related decline in the biosynthesis of mitochondrial inner membrane proteins.

Authors:  D L Marcus; N G Ibrahim; M L Freedman
Journal:  Exp Gerontol       Date:  1982       Impact factor: 4.032

9.  Benzodiazepine receptor binding in young, mature and senescent rat brain and kidney.

Authors:  N W Pedigo; H Schoemaker; M Morelli; J N McDougal; J B Malick; T F Burks; H I Yamamura
Journal:  Neurobiol Aging       Date:  1981       Impact factor: 4.673

10.  Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells.

Authors:  I Jung-Testas; Z Y Hu; E E Baulieu; P Robel
Journal:  Endocrinology       Date:  1989-10       Impact factor: 4.736
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  4 in total

1.  In thrombin stimulated human platelets Citalopram, Promethazine, Risperidone, and Ziprasidone, but not Diazepam, may exert their pharmacological effects also through intercalation in membrane phospholipids in a receptor-independent manner.

Authors:  Ramadhan Oruch; Erlend Hodneland; Ian F Pryme; Holm Holmsen
Journal:  J Chem Biol       Date:  2009-04-30

2.  Quantitative imaging of neuroinflammation in human white matter: a positron emission tomography study with translocator protein 18 kDa radioligand, [18F]-FEPPA.

Authors:  Ivonne Suridjan; Pablo M Rusjan; Miran Kenk; Nicolaas Paul L G Verhoeff; Aristotle N Voineskos; David Rotenberg; Alan A Wilson; Jeffrey H Meyer; Sylvain Houle; Romina Mizrahi
Journal:  Synapse       Date:  2014-07-28       Impact factor: 2.562

3.  Neuroinflammation in healthy aging: a PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [(18)F]-FEPPA.

Authors:  I Suridjan; P M Rusjan; A N Voineskos; T Selvanathan; E Setiawan; A P Strafella; A A Wilson; J H Meyer; S Houle; R Mizrahi
Journal:  Neuroimage       Date:  2013-09-21       Impact factor: 6.556

4.  Changes in peripheral benzodiazepine receptors in patients with bipolar disorder.

Authors:  Donatella Marazziti; Bernardo Dell'Osso; Stefano Baroni; Irene Masala; Elena Di Nasso; Gino Giannaccini; Liliana Dell'Osso
Journal:  Neuropsychiatr Dis Treat       Date:  2005-06       Impact factor: 2.570
  4 in total

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