Literature DB >> 8202664

Monospecific but not polyreactive human hybridoma rheumatoid factors exhibit preferential binding specificities for IgG3 and IgG4.

M M Newkirk1, J Rauch.   

Abstract

Among 38 human hybridoma-derived monoclonal rheumatoid factors (RFs) generated from patients with either rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), two groups of RFs can be identified. Monospecific RFs were derived primarily from patients with RA and are characterized by a binding specificity for IgG3 and/or IgG4. Polyreactive RFs were derived largely from patients with SLE and show a broader pattern of reactivity to all four isotypes of IgG. Neither population of RFs was exclusive to either disease. The binding specificities identified appear to be different from the RFs isolated from patients with mixed cryoglobulinemia and may reflect a different antigen selection mechanism.

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Year:  1994        PMID： 8202664     DOI： 10.1007/bf00390268

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  46 in total

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2.  IgG and IgA subclass distribution of total immunoglobulin and rheumatoid factors in rheumatoid tissue plasma cells.

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3.  Analysis of immunoglobulins secreted by hybridomas derived from rheumatoid synovia.

Authors:  C M Brown; C Plater-Zyberk; R A Mageed; R Jefferis; R N Maini
Journal:  Clin Exp Immunol       Date:  1990-06       Impact factor: 4.330

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Authors:  K James; G T Bell
Journal:  J Immunol Methods       Date:  1987-06-26       Impact factor: 2.303

5.  Restricted diversity of the variable region nucleotide sequences of the heavy and light chains of a human rheumatoid factor.

Authors:  I Ezaki; H Kanda; K Sakai; N Fukui; M Shingu; M Nobunaga; T Watanabe
Journal:  Arthritis Rheum       Date:  1991-03

6.  Polyspecific natural antibodies and autoantibodies secreted by human lymphocytes immortalized with Epstein-Barr virus.

Authors:  J M Seigneurin; B Guilbert; M J Bourgeat; S Avrameas
Journal:  Blood       Date:  1988-03       Impact factor: 22.113

7.  Hybridoma anti-DNA autoantibodies from patients with rheumatoid arthritis and systemic lupus erythematosus demonstrate similar nucleic acid binding characteristics.

Authors:  J Rauch; H Massicotte; H Tannenbaum
Journal:  J Immunol       Date:  1985-01       Impact factor: 5.422

8.  Frequencies of the separate human B cell subsets activatable to Ig secretion by Epstein-Barr virus and pokeweed mitogen.

Authors:  O Martínez-Maza; S Britton
Journal:  J Exp Med       Date:  1983-06-01       Impact factor: 14.307

9.  Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity.

Authors:  H G Kunkel; V Agnello; F G Joslin; R J Winchester; J D Capra
Journal:  J Exp Med       Date:  1973-02-01       Impact factor: 14.307

10.  Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments.

Authors:  M M Newkirk; R A Mageed; R Jefferis; P P Chen; J D Capra
Journal:  J Exp Med       Date:  1987-08-01       Impact factor: 14.307
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  1 in total

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Authors:  P Lévy-Soussan; A Berneman; M F Poirier; A Galinowski; H Loo; J P Olié; S Avrameas
Journal:  J Psychiatry Neurosci       Date:  1996-03       Impact factor: 6.186
  1 in total

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