Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Neurally expressed Drosophila genes encoding homologs of the NSF and SNAP secretory proteins.

Literature DB >> 8202553

Neurally expressed Drosophila genes encoding homologs of the NSF and SNAP secretory proteins.

Abstract

Several lines of investigation have now converged to indicate that the neurotransmitter release apparatus is formed by assembly of cytosolic proteins with proteins of the synaptic vesicle and presynaptic terminal membranes. We are undertaking a genetic approach in Drosophila melanogaster to investigate the functions of two types of cytosolic proteins thought to function in this complex: N-ethylmaleimide-sensitive fusion protein (NSF) and the soluble NSF attachment proteins (SNAPs). We have identified Drosophila homologs of the vertebrate and yeast NSF and SNAP genes. Both Drosophila genes encode polypeptides that closely resemble their vertebrate counterparts and are expressed in the nervous system; neither appears to be in a family of closely related Drosophila genes. These results indicate that the Drosophila NSF and SNAP genes are excellent candidates for mutational analysis of neurotransmitter release.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1994 PMID： 8202553 PMCID： PMC44067 DOI： 10.1073/pnas.91.12.5715

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

28 in total

Review 1. Molecular dissection of the secretory pathway.

Authors: J E Rothman; L Orci
Journal: Nature Date: 1992-01-30 Impact factor: 49.962

Review 2. Membrane fusion machinery: insights from synaptic proteins.

Authors: T C Südhof; P De Camilli; H Niemann; R Jahn
Journal: Cell Date: 1993-10-08 Impact factor: 41.582

Review 3. Coatomers and SNAREs in promoting membrane traffic.

Authors: P A Takizawa; V Malhotra
Journal: Cell Date: 1993-11-19 Impact factor: 41.582

4. Cell biology. Snappy exocytoxins.

Authors: W B Huttner
Journal: Nature Date: 1993-09-09 Impact factor: 49.962

5. Pattern-specific expression of the Drosophila decapentaplegic gene in imaginal disks is regulated by 3' cis-regulatory elements.

Authors: J D Masucci; R J Miltenberger; F M Hoffmann
Journal: Genes Dev Date: 1990-11 Impact factor: 11.361

6. Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway.

Authors: C A Kaiser; R Schekman
Journal: Cell Date: 1990-05-18 Impact factor: 41.582

7. Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans.

Authors: M S Perin; P A Johnston; T Ozcelik; R Jahn; U Francke; T C Südhof
Journal: J Biol Chem Date: 1991-01-05 Impact factor: 5.157

8. Synaptic transmission persists in synaptotagmin mutants of Drosophila.

Authors: A DiAntonio; K D Parfitt; T L Schwarz
Journal: Cell Date: 1993-07-02 Impact factor: 41.582

9. Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin.

Authors: M L Nonet; K Grundahl; B J Meyer; J B Rand
Journal: Cell Date: 1993-07-02 Impact factor: 41.582

10. SNAP receptors implicated in vesicle targeting and fusion.

Authors: T Söllner; S W Whiteheart; M Brunner; H Erdjument-Bromage; S Geromanos; P Tempst; J E Rothman
Journal: Nature Date: 1993-03-25 Impact factor: 49.962

19 in total

1. A temperature-sensitive paralytic mutant defines a primary synaptic calcium channel in Drosophila.

Authors: F Kawasaki; R Felling; R W Ordway
Journal: J Neurosci Date: 2000-07-01 Impact factor: 6.167

2. Biogenesis of Golgi stacks in imaginal discs of Drosophila melanogaster.

Authors: V Kondylis; S E Goulding; J C Dunne; C Rabouille
Journal: Mol Biol Cell Date: 2001-08 Impact factor: 4.138

3. The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic.

Authors: Helen A Lindsay; Richard Baines; Richard ffrench-Constant; Kathryn Lilley; Howard T Jacobs; Kevin M C O'Dell
Journal: Genetics Date: 2008-08-24 Impact factor: 4.562

4. Insight into Notch Signaling Steps That Involve pecanex from Dominant-Modifier Screens in Drosophila.

Authors: Tomoko Yamakawa; Yu Atsumi; Shiori Kubo; Ami Yamagishi; Izumi Morita; Kenji Matsuno
Journal: Genetics Date: 2018-05-31 Impact factor: 4.562

5. Cytokine exocytosis and JAK/STAT activation in the Drosophila ovary requires the vesicle trafficking regulator α-Snap.

Authors: Afsoon Saadin; Michelle Starz-Gaiano
Journal: J Cell Sci Date: 2018-11-30 Impact factor: 5.285

Review 6. Presynaptic proteins involved in exocytosis in Drosophila melanogaster: a genetic analysis.

Authors: J T Littleton; H J Bellen
Journal: Invert Neurosci Date: 1995

7. SNARE-complex disassembly by NSF follows synaptic-vesicle fusion.

Authors: J T Littleton; R J Barnard; S A Titus; J Slind; E R Chapman; B Ganetzky
Journal: Proc Natl Acad Sci U S A Date: 2001-10-02 Impact factor: 11.205

8. Genetic modifiers of the Drosophila NSF mutant, comatose, include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene, cacophony.

Authors: B Dellinger; R Felling; R W Ordway
Journal: Genetics Date: 2000-05 Impact factor: 4.562

9. Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants.

Authors: Fumiko Kawasaki; Richard W Ordway
Journal: Proc Natl Acad Sci U S A Date: 2009-08-11 Impact factor: 11.205

10. NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.

Authors: L A Tolar; L Pallanck
Journal: J Neurosci Date: 1998-12-15 Impact factor: 6.167